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AB231092

Anti-REG1 alpha antibody

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(1 Publication)

Rabbit Polyclonal LITH antibody. Suitable for WB, IHC-P and reacts with Rat, Recombinant full length protein - Rat, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Reg1.

View Alternative Names

Reg, Reg1, Lithostathine, Islet cells regeneration factor, Islet of Langerhans regenerating protein, Pancreatic stone protein, Pancreatic thread protein, ICRF, REG, PSP, PTP

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REG1 alpha antibody (AB231092)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REG1 alpha antibody (AB231092)

Formalin-fixed, paraffin-embedded rat intestine tissue stained for REG1 alpha using ab231092 at 20 μg/ml in immunohistochemical analysis, followed by DAB staining.

Western blot - Anti-REG1 alpha antibody (AB231092)
  • WB

Supplier Data

Western blot - Anti-REG1 alpha antibody (AB231092)

All lanes:

Western blot - Anti-REG1 alpha antibody (ab231092) at 2 µg/mL

All lanes:

Recombinant rat REG1 alpha protein

Predicted band size: 19 kDa

false

Western blot - Anti-REG1 alpha antibody (AB231092)
  • WB

Supplier Data

Western blot - Anti-REG1 alpha antibody (AB231092)

All lanes:

Western blot - Anti-REG1 alpha antibody (ab231092) at 2 µg/mL

Lane 1:

Rat pancreas lysate

Lane 2:

Mouse pancreas lysate

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit antibody at 1/1000 dilution

Predicted band size: 19 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Rat Reg1.

P10758

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Secondary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Recombinant full length protein - Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab231092 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

REG1 alpha also known as regenerating islet-derived protein 1 alpha or REG1A is a 19 kDa protein. Found primarily in the pancreas this protein also shows expression in gastric and intestinal tissues. REG1 alpha belongs to the C-type lectin superfamily known for their carbohydrate recognition capabilities. The protein involves itself directly in cell growth and proliferation through regenerative patterns essential for cellular homeostasis.
Biological function summary

The REG1 alpha protein stimulates pancreatic beta-cell proliferation influencing insulin production and secretion. It exists as a monomer but may participate in larger complexes during specific cellular responses. Its role expands to the modulation of cellular differentiation and inflammation control within the gastrointestinal tract. By aiding tissue repair REG1 alpha contributes to the maintenance of a healthy epithelial lining.

Pathways

The mitogen-activated protein kinase (MAPK) pathway sees REG1 alpha engaging in the regulation of cell proliferation by interacting with similar proteins involved in this signaling cascade. It also plays a role in the JAK-STAT pathway where it coordinates with the interleukins which are important for signaling that controls immune responses. REG1 alpha’s function in these pathways highlights its role in the regulation of growth and repair mechanisms.

REG1 alpha shows altered expression patterns in diabetes and some forms of cancer such as pancreatic cancer. In diabetes the protein’s involvement with glucose metabolism connects it to insulin regulation issues often interacting with insulin signaling proteins. In pancreatic cancer changes in REG1 alpha levels correlate with cellular growth and tissue regeneration processes that may become dysregulated further involving proteins like KRAS that stimulate cancer cell proliferation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Might act as an inhibitor of spontaneous calcium carbonate precipitation.
See full target information Reg1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 23:335 PubMed40089779

2025

F-box protein FBXO21 overexpression inhibits the proliferation and metastasis of clear cell renal cell carcinoma and is closely related to the CREB pathway and tumor immune cell infiltration.

Applications

Unspecified application

Species

Unspecified reactive species

Wuping Yang,Taile Jing,Cunjin Wu,Minghao Lu,Xiaolin Yao,Dan Xia,Ding Peng
View all publications
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Product promise

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