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AB70803

Anti-Relaxin 1 antibody

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(1 Publication)

Rabbit Polyclonal Relaxin 1 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 1 publication.

View Alternative Names

Prorelaxin H1, RLN1

1 Images
Western blot - Anti-Relaxin 1 antibody (AB70803)
  • WB

Supplier Data

Western blot - Anti-Relaxin 1 antibody (AB70803)

The antibody recognizes Relaxin-1 (~20 kDa) and its dimer form (~40 kDa) in samples from human (Jurkat cell lysate), and rat (kidney lysate). Other species have not been tested.

All lanes:

Western blot - Anti-Relaxin 1 antibody (ab70803)

Lane 1:

Jurkat cell lysate

Lane 2:

Rat kidney tissue lysate

Predicted band size: 21 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Prorelaxin H1. The exact immunogen used to generate this antibody is proprietary information.

P04808

Specificity

ab70803 recognizes Relaxin 1 (~20 kDa) and its dimer form (~40 kDa).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-4 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 3874 Relaxin-1 Antibody. 3874-100 is the same size as the 100 µg size of ab70803.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Relaxin 1 also known as RLN1 is a peptide hormone that plays a role in reproductive biology. It has a mass of approximately 6 kilodaltons. Relaxin 1 is expressed in various tissues mainly the reproductive system including the ovaries placenta and uterus. It modulates connective tissue remodeling which is important during childbirth by helping to relax the pelvic ligaments. Additionally it has effects on the cardiovascular and nervous systems.
Biological function summary

The hormone influences reproductive processes through its action on tissues affecting aspects like collagen remodeling and vasodilation. It does not form part of a complex but interacts with receptors such as RXFP1 which are G-protein-coupled receptors. The binding of Relaxin 1 to RXFP1 receptors activates several downstream signaling pathways that facilitate its biological functions.

Pathways

The role of Relaxin 1 extends beyond reproductive functions. It is involved in the extracellular matrix pathway and can influence the nitric oxide signaling pathway which impacts vascular relaxation and blood flow. Relaxin 1 related proteins include RXFP1 and its family member Relaxin 2 which can bind to the same receptor and trigger similar effects.

Relaxin 1 has a connection to fibrotic diseases and cardiovascular conditions. It exhibits antifibrotic properties reducing tissue scarring in organs like the skin and lungs. In cardiovascular diseases Relaxin 1 can help improve heart functions through its vasorelaxation effects. In these disease contexts Relaxin 1 interacts with proteins involved in the extracellular matrix and nitric oxide pathways to mediate its impact.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
See full target information Prorelaxin H1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Reproduction (Cambridge, England) 139:185-96 PubMed19812235

2009

Locally produced relaxin may affect testis and vas deferens function in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Lais Cavalca Cardoso,Aline Rosa Nascimento,Carine Royer,Catarina Segreti Porto,Maria Fatima Magalhaes Lazari
View all publications
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Product promise

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