Anti-Relaxin 3 receptor 1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Relaxin 3 receptor 1 also known as RXFP3 or GPCR135 is a G-protein-coupled receptor. This receptor has a molecular mass of about 55 kDa. RXFP3 is largely expressed in the brain particularly in the hypothalamus and other regions involved in stress response and appetite regulation. The receptor binds relaxin-3 which is the ligand activating its function.

Biological function summary

The RXFP3 receptor influences neuroendocrine signaling and is important for stress response feeding behaviors and possibly reproductive functioning. It does not appear to be part of a larger receptor complex. RXFP3 contributes to the release of neurotransmitters and modulates neuronal circuitry in areas of the brain responsible for these behaviors.

Pathways

RXFP3's activation involves signaling cascades like cAMP inhibition and MAPK/ERK pathways. It connects to related proteins such as gi/o proteins which transduce the signal from the RXFP3 activation to intracellular effectors. These pathways integrate the receptor’s role in affecting energy balance and stress response.

Associated diseases and disorders

RXFP3 has links to stress-related disorders and obesity. Research shows connections to depression with relaxin-3 and RXFP3 influencing mood regulation possibly through interactions with serotonin systems. Additionally RXFP3’s role in appetite control implicates it in metabolic disorders such as obesity potentially through its pathway cross-talk with leptin a hormone critical in regulating energy intake and expenditure.