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AB121394

Anti-RELL1 antibody

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(1 Publication)

Rabbit Polyclonal RELL1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RELL1 aa 100 to C-terminus.

View Alternative Names

PSEC0162, RELL1, RELT-like protein 1

6 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELL1 antibody (AB121394)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELL1 antibody (AB121394)

Immunohistochemical analysis of human gastrointestinal tissue labeling RELL1 with ab121394 at a 1/200 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-RELL1 antibody (AB121394)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-RELL1 antibody (AB121394)

ab121394, at 4 μg/ml, staining RELL1 in Human cell line U-2 OS by Immunofluorescence.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELL1 antibody (AB121394)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELL1 antibody (AB121394)

Immunohistochemical analysis of human skin tissue labeling RELL1 with ab121394 at a 1/200 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELL1 antibody (AB121394)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELL1 antibody (AB121394)

Immunohistochemical analysis of human lymphoid tissue labeling RELL1 with ab121394 at a 1/200 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELL1 antibody (AB121394)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELL1 antibody (AB121394)

Immunohistochemical analysis of human cerebral cortex tissue labeling RELL1 with ab121394 at a 1/200 dilution.

Western blot - Anti-RELL1 antibody (AB121394)
  • WB

Unknown

Western blot - Anti-RELL1 antibody (AB121394)

All lanes:

Western blot - Anti-RELL1 antibody (ab121394) at 0.4 µg/mL

All lanes:

human cell line RH-30

Predicted band size: 29 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human RELL1 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8IUW5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RELL1 also known as RELT-like 1 is part of the tumor necrosis factor receptor (TNFR) superfamily. It plays a role in signal transduction specifically in mediating survival and apoptotic signals. The protein has a molecular weight of approximately 40 kDa. It is expressed in various tissues including the lung liver spleen and immune-related cells such as T and B lymphocytes.
Biological function summary

RELL1 contributes to immune system regulation by interacting with other TNFR family members and modulating signaling pathways that influence cell death and survival. It often engages in forming receptor-ligand complexes to execute its function. The protein's activity may affect processes such as inflammation and immune responses.

Pathways

The TNF signaling and NF-kappaB pathways are relevant to RELL1. These pathways are critical for transmitting signals that lead to either cell survival or apoptosis. RELL1 interacts with proteins such as TRAF2 and TRAF3 which are instrumental in mediating downstream signaling events within these pathways.

RELL1 has connections with autoimmune diseases and cancers. Its influence on immune cell regulation can contribute to autoimmune conditions by altering immune tolerance. Additionally aberrant signaling through pathways involving RELL1 can affect cell proliferation linking it to certain cancer types. The protein's interaction with TNFR family members like TNFR1 can exacerbate these conditions reflecting its potential importance in therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed : 28688764). Induces apoptosis, when overexpressed (PubMed : 19969290).
See full target information RELL1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 12:42 PubMed33414446

2021

TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.

Applications

Unspecified application

Species

Unspecified reactive species

Susu Guo,Yuxin Chen,Yueyue Yang,Xiao Zhang,Lifang Ma,Xiangfei Xue,Yongxia Qiao,Jiayi Wang
View all publications
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Product promise

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