Rabbit Polyclonal RELL1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human RELL1 aa 100 to C-terminus.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human RELL1 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q8IUW5
Reactivity data
Select an application| IHC-P | WB | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes - |
Target data
Function
Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290).
Alternative names
PSEC0162, RELL1, RELT-like protein 1
Recommended products
Rabbit Polyclonal RELL1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human RELL1 aa 100 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human RELL1 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q8IUW5
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
RELL1 also known as RELT-like 1 is part of the tumor necrosis factor receptor (TNFR) superfamily. It plays a role in signal transduction specifically in mediating survival and apoptotic signals. The protein has a molecular weight of approximately 40 kDa. It is expressed in various tissues including the lung liver spleen and immune-related cells such as T and B lymphocytes.
- Biological function summary
RELL1 contributes to immune system regulation by interacting with other TNFR family members and modulating signaling pathways that influence cell death and survival. It often engages in forming receptor-ligand complexes to execute its function. The protein's activity may affect processes such as inflammation and immune responses.
- Pathways
The TNF signaling and NF-kappaB pathways are relevant to RELL1. These pathways are critical for transmitting signals that lead to either cell survival or apoptosis. RELL1 interacts with proteins such as TRAF2 and TRAF3 which are instrumental in mediating downstream signaling events within these pathways.
- Associated diseases and disorders
RELL1 has connections with autoimmune diseases and cancers. Its influence on immune cell regulation can contribute to autoimmune conditions by altering immune tolerance. Additionally aberrant signaling through pathways involving RELL1 can affect cell proliferation linking it to certain cancer types. The protein's interaction with TNFR family members like TNFR1 can exacerbate these conditions reflecting its potential importance in therapeutic targets.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
6 product images
Immunocytochemistry/ Immunofluorescence - Anti-RELL1 antibody (ab121394)
ab121394, at 4 μg/ml, staining RELL1 in Human cell line U-2 OS by Immunofluorescence.
Western blot - Anti-RELL1 antibody (ab121394)
All lanes: Western blot - Anti-RELL1 antibody (ab121394) at 0.4 µg/mL
All lanes: human cell line RH-30
Predicted band size: 29 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELL1 antibody (ab121394)
Immunohistochemical analysis of human gastrointestinal tissue labeling RELL1 with ab121394 at a 1/200 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELL1 antibody (ab121394)
Immunohistochemical analysis of human skin tissue labeling RELL1 with ab121394 at a 1/200 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELL1 antibody (ab121394)
Immunohistochemical analysis of human lymphoid tissue labeling RELL1 with ab121394 at a 1/200 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELL1 antibody (ab121394)
Immunohistochemical analysis of human cerebral cortex tissue labeling RELL1 with ab121394 at a 1/200 dilution.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com