AB39626

Anti-RELM alpha/Retnla antibody

Name: Anti-RELM alpha/Retnla antibody. Rabbit polyclonal (ab39626) | Abcam
Brand: Abcam Limited
SKU: AB39626
Price: 585 USD
Availability: InStock
Rating: 5 (4 reviews)

(4 Reviews)

(41 Publications)

Rabbit Polyclonal RELM alpha/Retnla antibody. Suitable for ELISA, WB, IHC-P, IHC-Fr and reacts with Mouse samples. Cited in 41 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Retnla.

View Alternative Names

Fizz1, Himf, Pmng1, Retnla, Resistin-like alpha, Cysteine-rich secreted protein A12-gamma, Cysteine-rich secreted protein FIZZ1, Hypoxia-induced mitogenic factor, Parasite-induced macrophage novel gene 1 protein, RELMalpha

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

IHC-Fr, ELISA, IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Retnla.

Q9EP95

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

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Product details

Although some customers have been successful in IHC we no longer batch test in this application.

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Properties and storage information

Form

Lyophilized

Reconstitution

reconstitute with water at 0.2mg/mL

Purification technique

Affinity purification Immunogen

Storage buffer

Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RELM alpha also known as Retnla is a small secreted protein with a molecular mass of approximately 10 kDa. It belongs to the resistin-like molecule family and is mainly expressed in adipose tissues and the lungs. However some expression also occurs in the gastrointestinal tract and immune cells. It plays a role as a signaling molecule and is secreted under various physiological and pathological conditions.

Biological function summary

RELM alpha functions as a modulator of immune responses and inflammation. It has a part in the immune network and participates in the regulation of insulin sensitivity. While it does not form part of a specific complex it interacts with other cytokines and chemokines to modulate the activity of macrophages and other immune cells. This modulation impacts the balance between pro-inflammatory and anti-inflammatory signals in the body.

Pathways

RELM alpha plays roles in the metabolic and immune pathways. It influences the toll-like receptor signaling pathway which involves key proteins like TLR4 which is essential for pathogen recognition and innate immunity. RELM alpha also appears in pathways related to glucose metabolism interacting with other metabolic regulators to affect energy homeostasis and insulin action.

RELM alpha has connections to conditions like obesity and asthma. In obesity levels of RELM alpha may correlate with inflammatory states and insulin resistance interacting with proteins like adiponectin and leptin. In asthma RELM alpha may contribute to airway inflammation working alongside proteins like IL-13 to drive inflammatory responses in the respiratory system. These associations make RELM alpha a significant target for therapeutic investigation in related disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Probable hormone. Plays a role in pulmonary vascular remodeling.

See full target information Retnla

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Publications (41)

Recent publications for all applications. Explore the full list and refine your search

Respiratory research 25:428 PubMed39633343

2024

T follicular helper cell is essential for M2 macrophage polarization and pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Li,Pingping Liu,Hao Zhu,Huan Yang,Jun Zha,Huiling Yao,Shaoze Zhang,Jin Huang,Guang Li,Gang Jiang,Yongliang Jiang,Aiguo Dai

Frontiers in pharmacology 15:1460692 PubMed39386033

2024

Airspaces-derived exosomes contain disease-relevant protein signatures in a mouse model of cystic fibrosis (CF)-like mucoinflammatory lung disease.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Mao,Amol Suryawanshi,Sonika Patial,Yogesh Saini

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 73:725-737 PubMed38538755

2024

Bakuchicin alleviates ovalbumin-induced allergic asthma by regulating M2 macrophage polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Yeon-Yong Kim,Seungwon Jeong,Seung Woong Lee,Seung-Jae Lee,Mun-Chual Rho,Sang-Hyun Kim,Soyoung Lee

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e23259 PubMed37855749

2023

Macrophage RAGE deficiency prevents myocardial fibrosis by repressing autophagy-mediated macrophage alternative activation.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaqi He,Lan Wei,Shengan Tan,Birong Liang,Jing Liu,Lu Lu,Ting Wang,Junyan Wang,Yusheng Huang,Zixin Chen,Huan Li,Lu Zhang,Zheng Zhou,Yanhong Cao,Xiaohan Ye,Zhongqi Yang,Shaoxiang Xian,Lingjun Wang

iScience 26:107496 PubMed37636061

2023

Galectin-3 as TREM2 upstream factor contributes to lung ischemia-reperfusion injury by regulating macrophage polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Liu,Lu Zhang,Zhen Liu,Jinyuan Lin,Xiaojing He,Siyi Wu,Yi Qin,Chen Zhao,Youyuan Guo,Fei Lin

Frontiers in pharmacology 14:1145188 PubMed36998616

2023

Artesunate inhibits airway remodeling in asthma the MAPK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mengyuan Zhang,Jiangtao Lin,Jingyuan Zhang,Ruiheng Zhao,Jingxuan Wan,Ying Nong

American journal of translational research 14:8129-8145 PubMed36505286

2022

MiR-216b targets CPEB4 to suppress colorectal cancer progression through inhibiting IL-10-mediated M2 polarization of tumor-associated macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Zou,Boyu Wu,Chao Lin,Qunhua Ding,Jiangtao Li

Methods and protocols 5: PubMed36136814

2022

In Vitro Screening Method for Characterization of Macrophage Activation Responses.

Applications

Unspecified application

Species

Unspecified reactive species

Brandon W Lewis,Sonika Patial,Yogesh Saini

Cell : PubMed35777355

2022

A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Zhang,Yibin Zhu,Ziwen Liu,Yongmei Peng,Wenyu Peng,Liangqin Tong,Jinglin Wang,Qiyong Liu,Penghua Wang,Gong Cheng

Stem cell research & therapy 13:109 PubMed35313972

2022

Human umbilical cord-derived mesenchymal stem cells alleviate insulin resistance in diet-induced obese mice via an interaction with splenocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Xue,Jieqing Gao,Yulin Gu,Aihong Wang,Songyan Yu,Bing Li,Yaqi Yin,Jie Wang,Wanlu Su,Haixia Zhang,Weizheng Ren,Weijun Gu,Zhaohui Lv,Yiming Mu,Yu Cheng

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-RELM alpha/Retnla antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Reconstitution

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (41)

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