AB11429

Anti-RELM beta antibody

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(7 Publications)

Rabbit Polyclonal RELM beta antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Retnlb.

View Alternative Names

Fizz2, Retnlb, Resistin-like beta, Cysteine-rich secreted protein A12-beta, Cysteine-rich secreted protein FIZZ2, RELMbeta

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELM beta antibody (AB11429)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELM beta antibody (AB11429)

ab11429 labelling RELM in Mouse colon tissue sections by Immunohistochemistry (formalin/PFA-fixed paraffin-embedded sections).

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELM beta antibody (AB11429)

ab11429 labelling RELM in Mouse colon tissue sections by Immunohistochemistry (formalin/PFA-fixed paraffin-embedded sections).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Retnlb.

Q99P86

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.05% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RELM beta also known as Resistin-Like Molecule Beta or FIZZ2 is a cysteine-rich secreted protein with an approximate mass of 19 kDa. This protein expresses mainly in tissues like the colon small intestine and adipose tissue. It belongs to the resistin-like molecule (RELM) family which is known for its similarities in amino acid sequence and structural features. RELM beta usually gets secreted by epithelial cells particularly in the intestinal region which suggests its active involvement in the gut environment.

Biological function summary

The RELM beta protein modulates immune responses and interacts with elements of the metabolic processes. It plays a role in bridging innate and adaptive immunity affecting inflammatory cascades through its cytokine-like activities. Although it is not part of a large complex RELM beta influences receptor signaling pathways and can affect macrophages and other immune cells. Its activity on energy homeostasis and glucose metabolism indicates key interactions in metabolic pathways influencing overall cellular functions.

Pathways

RELM beta prominently interacts with pathways involved in inflammation and metabolism. It participates in the NF-kB signaling pathway which is a central mediator in inflammation and immune responses. Also it connects to the adipokine signaling pathway where it works alongside other resistin family proteins. Through these pathways RELM beta coordinates with proteins like TNF-alpha and IL-6 in modulating inflammation and energy balance.

RELM beta relates to conditions such as inflammatory bowel disease (IBD) and type 2 diabetes. Its increased expression associates with elevated inflammatory states found in IBD and insights suggest a role in disease progression through interactions with proteins like IL-1β. In type 2 diabetes the regulation of glucose homeostasis implicates RELM beta as a participant in metabolic dysregulation. Changes in RELM beta expression can influence risk factors potentially in conjunction with other mediators like insulin.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Probable hormone.

See full target information Retnlb

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:e2004162 PubMed34378353

2021

The Transcription Factor SUB1 Is a Master Regulator of the Macrophage TLR Response in Atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Rongzhong Huang,Zicheng Hu,Xiaorui Chen,Yu Cao,Hongrong Li,Hong Zhang,Yongyong Li,Liwen Liang,Yuxing Feng,Ying Wang,Wenhua Su,Zerui Kong,N D Melgiri,Lihong Jiang,Xingsheng Li,Jianlin Du,Yunqing Chen

Arthritis research & therapy 22:75 PubMed32272965

2020

Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Ran Li,Kunchi Zhao,Qing Ruan,Chunyang Meng,Fei Yin

PLoS pathogens 15:e1007657 PubMed30998782

2019

TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Nicola Steel,Aduragbemi A Faniyi,Sayema Rahman,Stefanie Swietlik,Beata I Czajkowska,Bethany T Chan,Alexander Hardgrave,Anthony Steel,Tim D Sparwasser,Mushref B Assas,Richard K Grencis,Mark A Travis,John J Worthington

The international journal of biochemistry & cell biology 105:52-60 PubMed30120989

2018

TGF-β1-induced SMAD2/3/4 activation promotes RELM-β transcription to modulate the endothelium-mesenchymal transition in human endothelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yongliang Jiang,Xuanfen Zhou,Ruicheng Hu,Aiguo Dai

Drug metabolism and disposition: the biological fa 45:982-989 PubMed28646079

2017

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria.

Applications

Unspecified application

Species

Unspecified reactive species

Flora Scott,Sandra G Gonzalez Malagon,Brett A O'Brien,Diede Fennema,Sunil Veeravalli,Clarissa R Coveney,Ian R Phillips,Elizabeth A Shephard

JPEN. Journal of parenteral and enteral nutrition 40:1042-9 PubMed25934045

2015

Bombesin Preserves Goblet Cell Resistin-Like Molecule β During Parenteral Nutrition but Not Other Goblet Cell Products.

Applications

Unspecified application

Species

Unspecified reactive species

Rebecca A Busch,Aaron F Heneghan,Joseph F Pierre,Joshua C Neuman,Claire A Reimer,Xinying Wang,Michelle E Kimple,Kenneth A Kudsk

DNA repair 9:785-95 PubMed20466601

2010

Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.

Applications

Unspecified application

Species

Unspecified reactive species

Mansour Akbari,Karin Solvang-Garten,Audun Hanssen-Bauer,Nora Valeska Lieske,Henrik Sahlin Pettersen,Grete Klippenvåg Pettersen,David M Wilson,Hans E Krokan,Marit Otterlei

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-RELM beta antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELM beta antibody (AB11429)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RELM beta antibody (AB11429)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Complementary Products

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (7)

Product promise