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AB236560

Anti-Renalase antibody [RNLS/1940]

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(1 Publication)

Mouse Monoclonal Renalase antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RNLS aa 1-250.

View Alternative Names

C10orf59, RNLS, Renalase, Monoamine oxidase-C, MAO-C

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Renalase antibody [RNLS/1940] (AB236560)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Renalase antibody [RNLS/1940] (AB236560)

Formalin-fixed, paraffin-embedded human kidney tissue stained for Renalase using ab236560 at 2 μg/ml in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Renalase antibody [RNLS/1940] (AB236560)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Renalase antibody [RNLS/1940] (AB236560)

Formalin-fixed, paraffin-embedded human kidney tissue stained for Renalase using ab236560 at 2 μg/ml in immunohistochemical analysis.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

RNLS/1940

Isotype

IgG2b

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human RNLS aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q5VYX0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p>Incubate with primary antibody for 30 minutes at RT.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Purified from bioreactor concentrate by Protein A/G.
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Renalase also known as RNLS is a flavoprotein that catalyzes the oxidation of catecholamines such as dopamine and norepinephrine. It has a mass of approximately 37 kDa. The protein is expressed in the kidney heart and other tissues including the liver and brain. Its enzymatic activity helps in regulating blood pressure and cardiac function by metabolizing circulating monoamines.
Biological function summary

Renalase impacts the cardiovascular system through its enzymatic function that reduces systemic catecholamine levels. It has been shown the protein interacts with catecholamines beyond the boundaries of a simple enzymatic reaction. Renalase may form complexes with other enzymes that participate in detoxifying catecholamines. Researchers have studied its effects on catecholamine-related stress responses highlighting a potential modulatory function beyond simple substrate degradation.

Pathways

The metabolism of catecholamines involves Renalase in the regulation of the sympathetic nervous system and its associated pathways. Renalase fits into the catecholamine degradation pathway where it works alongside other enzymes such as monoamine oxidase which also breaks down neurotransmitters. These actions influence the broader systemic pathways associated with cardiovascular health by maintaining a balance in neurotransmitter levels and resultant blood pressure regulation.

Renalase has been associated with hypertension due to its role in catecholamine metabolism. Abnormal Renalase function can contribute to increased circulating catecholamines leading to elevated blood pressure. Additionally studies have suggested a link between Renalase and chronic kidney disease where alterations in Renalase activity may exacerbate kidney dysfunction. The relationship between Renalase and proteins like angiotensin-converting enzyme (ACE) further hints at its potential involvement in blood pressure regulation and renal pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
See full target information RNLS
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Medicine 100:e25028 PubMed33761659

2021

Clinicopathological significance of SOX4 and epithelial-mesenchymal transition markers in patients with laryngeal squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Mingjie Zhang,Hui Li,Yuefeng Han,Mengjun Wang,Junjie Zhang,Shiyin Ma
View all publications
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Product promise

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