Rabbit Polyclonal Renin Receptor antibody. Suitable for WB, ICC/IF and reacts with Human, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human ATP6AP2 aa 100-350.
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ATP6IP2, CAPER, ELDF10, HT028, MSTP009, PSEC0072, ATP6AP2, Renin receptor, ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H(+)-transporting lysosomal-interacting protein 2, ER-localized type I transmembrane adapter, Embryonic liver differentiation factor 10, N14F, Renin/prorenin receptor, Vacuolar ATP synthase membrane sector-associated protein M8-9, ATP6M8-9, V-ATPase M8.9 subunit
- ICC/IF
Unknown
Immunocytochemistry/ Immunofluorescence - Anti-Renin Receptor antibody (AB151241)
Immunofluorescence analysis of methanol-fixed HepG2 cells labeling Renin Receptor with ab151241 at 1/200 dilution. The image in the lower panel is costained with Hoechst 33342.
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-Renin Receptor antibody (AB151241)
Immunofluorescence analysis of HeLa cells fixed in ice-cold MeOH for 5 min labelling Renin Receptor protein at endoplasmic reticulum using ab151241 at a 1/500 dilution (Green).
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-Renin Receptor antibody (AB151241)
Immunofluorescence analysis of DIV9 rat hippocampal neuron cells fixed in 4% paraformaldehyde at RT for 15 min labelling Renin Receptor protein using ab151241 at a 1/500 dilution (Green). Tau, a Axon marker, stained by Tau antibody at a 1/500 dilution (Red). DAPI was used for nuclear staining (Blue).
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cathepsin L/V/K/H antibody [EPR8011] (AB133641)](https://content.abcam.com/products/images/cathepsin-l-v-k-h-antibody-epr8011-ab133641--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img33318.jpg)
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Reactivity data
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Biological function summary
The Renin Receptor participates in maintaining homeostasis within the renin-angiotensin-aldosterone system. It potentially forms part of a larger receptor complex by interacting with other pathway components. By modulating the activity of renin and prorenin it enhances blood pressure regulation and fluid balance contributing to cardiovascular function and cellular ion homeostasis. Its involvement extends to promoting cell signaling events related to growth development and metabolism through the MAPK pathway.
Pathways
The Renin Receptor integrates into the renin-angiotensin system and the Wnt signaling pathway. In the renin-angiotensin system the receptor interacts with proteins such as angiotensin-converting enzyme (ACE) and angiotensin receptors playing an important role in blood pressure and electrolyte balance. Its engagement in the Wnt pathway suggests a role in development and cellular proliferation highlighting its interaction with proteins involved in cellular communication and embryonic development.
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