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AB26810

Anti-Reovirus p17 protein antibody

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(1 Publication)

Rabbit Polyclonal Reovirus p17 protein antibody. Suitable for WB, ELISA and reacts with Recombinant full length protein - Reovirus sp., Reovirus sp. samples. Cited in 1 publication.

View Alternative Names

Avian reovirus p17 protein

1 Images
Western blot - Anti-Reovirus p17 protein antibody (AB26810)
  • WB

Supplier Data

Western blot - Anti-Reovirus p17 protein antibody (AB26810)

Western blot analysis of Reovirus p17 protein.

All lanes : Anti-Reovirus p17 protein antibody (ab26810) at 1/500 dilution

Lane 1 : p17 recombinant protein

Lane 2 : pcDNA3.1

All lanes:

Western blot - Anti-Reovirus p17 protein antibody (ab26810)

Predicted band size: 17 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Reovirus sp.

Applications

ELISA, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant full length protein - Reovirus sp.": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>", "ELISA-species-checked": "notRecommended", "ELISA-species-dilution-info": "", "ELISA-species-notes": "" }, "Reovirus sp.": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/50000", "ELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Reovirus p17 protein also known as σ1s serves as a non-structural component of the Reovirus. This protein has a molecular mass of about 17 kDa and localizes within infected host cells. Its expression occurs during the early stages of infection where it engages in interaction with the host cell machinery. Reovirus p17 is essential for successful viral replication and acts as a modulator by affecting the synthesis and stability of viral RNA.
Biological function summary

The Reovirus p17 protein influences the host cell environment to favor viral replication processes. It operates as part of a viral replication complex forming associations with other viral proteins to assist in viral RNA replication and assembly of new viral particles. p17 can interfere with host cellular functions impacting the cell cycle and immune responses which helps in the persistence and multiplication of the virus within the host.

Pathways

Changes instigated by Reovirus p17 protein affect the apoptosis and autophagy pathways in host cells. The protein may enhance apoptosis by interacting with pathways involving caspase proteins leading to programmed cell death. Additionally p17 can influence autophagy pathways which are important for the degradation and recycling of cellular components. This interaction can help in evasion from the host immune system facilitating viral replication and spread.

Research links the Reovirus p17 protein to certain viral pathologies such as encephalitis and respiratory infections. p17's interaction with host proteins like immune receptors can exacerbate disease processes by modifying immune response pathways. By understanding these interactions scientists hope to develop potential therapeutic targets that can mitigate the severity of diseases caused by reovirus infections.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Reovirus p17 protein
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 19:715-727 PubMed31476618

2019

Pim1 Impacts Enterovirus A71 Replication and Represents a Potential Target in Antiviral Therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Fanghang Zhou,Qianya Wan,Jing Lu,Ying Chen,Gui Lu,Ming-Liang He
View all publications
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Product promise

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