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AB217756

Anti-RERE antibody

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(1 Publication)

Rabbit Polyclonal RERE antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RERE aa 550-600 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

ARG, ARP, ATN1L, KIAA0458, RERE, Arginine-glutamic acid dipeptide repeats protein, Atrophin-1-like protein, Atrophin-1-related protein

1 Images
Western blot - Anti-RERE antibody (AB217756)
  • WB

Supplier Data

Western blot - Anti-RERE antibody (AB217756)

8% gel.

All lanes:

Western blot - Anti-RERE antibody (ab217756) at 1/300 dilution

All lanes:

A549 cell lysates

Secondary

All lanes:

Goat anti-rabbit IgG (H+L), HRP at 1/5000 dilution

Predicted band size: 172 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human RERE aa 550-600 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9P2R6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RERE also known as arginine-glutamic acid dipeptide repeats protein functions as a nuclear protein involved in transcription regulation. It has a molecular mass of approximately 170 kDa. Scientists find RERE expression in many tissues with heightened levels in the brain particularly in regions engaged in cognitive functions. This protein modulates gene expression by interacting with other transcriptional co-regulators influencing critical developmental processes.
Biological function summary

RERE impacts embryonic development and neurogenesis. It acts as part of a complex which includes proteins like ATN1 contributing to histone modification and chromatin remodeling. RERE influences cell fate by regulating the transcription of target genes necessary for proper neural development. By modulating gene expression RERE plays a significant role in the development of several organs notably the brain and heart.

Pathways

Various genetic and signal transduction cascades involve RERE. It participates in the retinoic acid signaling pathway where it interacts with retinoic acid receptors influencing gene transcription essential for embryonic development. Additionally the protein participates in the Wnt signaling pathway associated with cellular proliferation and differentiation interacting with proteins such as β-catenin to ensure proper signaling outcomes.

RERE mutations associate with developmental disorders particularly neurodevelopmental disorders like intellectual disability. Moreover disruptions in RERE function link to certain congenital heart defects. Deficiency or malfunction in RERE may also impact proteins like SHH (Sonic Hedgehog) implicated in developmental pathways highlighting its potential involvement in signaling defects associated with these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.
See full target information RERE
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Regenerative therapy 20:165-186 PubMed35620640

2022

Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish.

Applications

Unspecified application

Species

Unspecified reactive species

Tsubasa Saeki,Sho Yoshimatsu,Mitsuru Ishikawa,Chung-Chau Hon,Ikuko Koya,Shinsuke Shibata,Makoto Hosoya,Chika Saegusa,Kaoru Ogawa,Jay W Shin,Masato Fujioka,Hideyuki Okano
View all publications
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Product promise

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