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Anti-Respiratory Syncytial Virus fusion protein antibody [RSV3216 (B016)] (ab24011) is a mouse monoclonal antibody that is used to detect Respiratory Syncytial Virus fusion protein in Western Blot, Flow Cytometry, IP, ICC/IF, ELISA, EM. Suitable for Respiratory syncytial virus samples.



- Trusted since 2005


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Key facts

Isotype
IgG2b
Host species
Mouse
Storage buffer

pH: 7.5
Preservative: 0.1% Sodium azide
Constituents: PBS

Form
Liquid
Clonality
Monoclonal

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IPEMFlow CytWBsELISAICC/IF
Respiratory syncytial virus
Expected
Expected
Expected
Expected
Expected
Expected

Expected
Expected

Species
Respiratory syncytial virus
Dilution info
Use at an assay dependent concentration.
Notes

-

Expected
Expected

Species
Respiratory syncytial virus
Dilution info
Use at an assay dependent concentration.
Notes

-

Expected
Expected

Species
Respiratory syncytial virus
Dilution info
-
Notes

ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

Expected
Expected

Species
Respiratory syncytial virus
Dilution info
Use at an assay dependent concentration.
Notes

-

Expected
Expected

Species
Respiratory syncytial virus
Dilution info
-
Notes

Use ab34992 as capture antibody

Expected
Expected

Species
Respiratory syncytial virus
Dilution info
Use at an assay dependent concentration.
Notes

-

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Anti-Respiratory Syncytial Virus fusion protein antibody [RSV3216 (B016)] (ab24011) is a mouse monoclonal antibody that is used to detect Respiratory Syncytial Virus fusion protein in Western Blot, Flow Cytometry, IP, ICC/IF, ELISA, EM. Suitable for Respiratory syncytial virus samples.



- Trusted since 2005

Key facts

Isotype
IgG2b
Form
Liquid
Clonality
Monoclonal
Clone number
RSV3216 (B016)
Purification technique
Affinity purification Protein A
Specificity

Recognises a Respiratory Syncytial Virus fusion protein (46kD and 22kD s-s linked glycoprotein).

Concentration
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Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot

Notes

What is this antibody validated in?


Anti-Respiratory Syncytial Virus fusion protein antibody [RSV3216 (B016)] (ab24011) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF), ELISA, Electron microscopy (EM), in Respiratory syncytial virus samples.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

The Respiratory Syncytial Virus (RSV) fusion protein also called F protein is critical in the viral entry process. It facilitates the fusion of the viral envelope with the host cell membrane permitting the viral RNA to enter the host cell. The fusion protein is a trimeric glycoprotein expressed on the surface of the RSV virion and has a molecular mass of approximately 64 kDa. The protein undergoes maturation through proteolytic processing which is important for its function. RSV fusion protein is primarily expressed in the respiratory tract during infections.

Biological function summary

The RSV fusion protein plays a pivotal role in initiating infection by mediating the fusion of the virus with the host cell membrane. It forms part of a complex that includes other viral envelope glycoproteins such as the attachment (G) protein facilitating viral binding and fusion. The conformational change in the fusion protein triggers the merging of the viral envelope with the host cell membrane an essential step for viral replication and spread within the host.

Pathways

Fusion protein contributes significantly to the viral infection pathway of RSV. During virus-host cell interaction the fusion protein engages with cell surface receptors like nucleolin part of the viral entry pathway. Additionally the fusion protein's activity is related to the broader class I viral fusion proteins which includes influenza hemagglutinin detailing its fundamental role in viral pathogenesis and immune evasion strategies.

Associated diseases and disorders

The RSV fusion protein is a major factor in illnesses such as bronchiolitis and pneumonia particularly in young children and immunocompromised patients. The fusion protein's activity is associated with the exacerbation of these respiratory conditions. It also interacts with proteins like the G protein during infection which can influence RSV pathogenicity and the host's immune response. Understanding these interactions helps in the development of therapeutic and preventative strategies against RSV-related diseases.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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