Anti-Respiratory Syncytial Virus fusion protein antibody [RSV3216 (B016)] (ab24011) is a mouse monoclonal antibody that is used to detect Respiratory Syncytial Virus fusion protein in Western Blot, Flow Cytometry, IP, ICC/IF, ELISA, EM. Suitable for Respiratory syncytial virus samples.
- Trusted since 2005
pH: 7.5
Preservative: 0.1% Sodium azide
Constituents: PBS
IP | EM | Flow Cyt | WB | sELISA | ICC/IF | |
---|---|---|---|---|---|---|
Respiratory syncytial virus | Expected | Expected | Expected | Expected | Expected | Expected |
Species | Dilution info | Notes |
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Species Respiratory syncytial virus | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
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Species Respiratory syncytial virus | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
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Species Respiratory syncytial virus | Dilution info - | Notes ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Species | Dilution info | Notes |
---|---|---|
Species Respiratory syncytial virus | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
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Species Respiratory syncytial virus | Dilution info - | Notes Use ab34992 as capture antibody |
Species | Dilution info | Notes |
---|---|---|
Species Respiratory syncytial virus | Dilution info Use at an assay dependent concentration. | Notes - |
F
Anti-Respiratory Syncytial Virus fusion protein antibody [RSV3216 (B016)] (ab24011) is a mouse monoclonal antibody that is used to detect Respiratory Syncytial Virus fusion protein in Western Blot, Flow Cytometry, IP, ICC/IF, ELISA, EM. Suitable for Respiratory syncytial virus samples.
- Trusted since 2005
pH: 7.5
Preservative: 0.1% Sodium azide
Constituents: PBS
Recognises a Respiratory Syncytial Virus fusion protein (46kD and 22kD s-s linked glycoprotein).
The Respiratory Syncytial Virus (RSV) fusion protein also called F protein is critical in the viral entry process. It facilitates the fusion of the viral envelope with the host cell membrane permitting the viral RNA to enter the host cell. The fusion protein is a trimeric glycoprotein expressed on the surface of the RSV virion and has a molecular mass of approximately 64 kDa. The protein undergoes maturation through proteolytic processing which is important for its function. RSV fusion protein is primarily expressed in the respiratory tract during infections.
The RSV fusion protein plays a pivotal role in initiating infection by mediating the fusion of the virus with the host cell membrane. It forms part of a complex that includes other viral envelope glycoproteins such as the attachment (G) protein facilitating viral binding and fusion. The conformational change in the fusion protein triggers the merging of the viral envelope with the host cell membrane an essential step for viral replication and spread within the host.
Fusion protein contributes significantly to the viral infection pathway of RSV. During virus-host cell interaction the fusion protein engages with cell surface receptors like nucleolin part of the viral entry pathway. Additionally the fusion protein's activity is related to the broader class I viral fusion proteins which includes influenza hemagglutinin detailing its fundamental role in viral pathogenesis and immune evasion strategies.
The RSV fusion protein is a major factor in illnesses such as bronchiolitis and pneumonia particularly in young children and immunocompromised patients. The fusion protein's activity is associated with the exacerbation of these respiratory conditions. It also interacts with proteins like the G protein during infection which can influence RSV pathogenicity and the host's immune response. Understanding these interactions helps in the development of therapeutic and preventative strategies against RSV-related diseases.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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