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AB94966

Anti-Respiratory Syncytial Virus G Glycoprotein antibody [RSV133]

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(14 Publications)

Anti-Respiratory Syncytial Virus G Glycoprotein antibody [RSV133] (ab94966) is a mouse monoclonal antibody detecting Respiratory Syncytial Virus G Glycoprotein in Western Blot, IHC-Fr, ICC/IF, ELISA. Suitable for Respiratory syncytial virus.

- Trusted since 2010

View Alternative Names

Major surface glycoprotein G, Attachment glycoprotein G, Membrane-bound glycoprotein, mG, G

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

RSV133

Isotype

IgG1

Carrier free

No

Reacts with

Respiratory syncytial virus

Applications

IHC-Fr, ELISA, WB, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Respiratory syncytial virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Fix with Acetone.</p>" } } }
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Product details

What is this antibody validated in?
Anti-Respiratory Syncytial Virus G Glycoprotein antibody [RSV133] (ab94966) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF), ELISA in Respiratory syncytial virus samples.

What is the molecular weight of Respiratory Syncytial Virus G Glycoprotein?
Anti-Respiratory Syncytial Virus G Glycoprotein [RSV133] (ab94966) specifically detects a band for Respiratory Syncytial Virus G Glycoprotein (UniProt: P03423) at a molecular weight of 33kDa.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.02% Sodium azide Constituents: 99.98% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Respiratory Syncytial Virus G Glycoprotein also known as RSV G protein plays a significant mechanical role in the virus's lifecycle. This glycoprotein with a molecular mass of approximately 90 kDa is expressed on the surface of the Respiratory Syncytial Virus (RSV). RSV G protein primarily facilitates viral attachment to host cells by binding to heparan sulfate on the cell surface. This attachment serves as an initial step for viral infection aiding RSV in invading epithelial cells of the respiratory tract.
Biological function summary

The RSV G protein contributes to immune evasion and modulation within the host. By mimicking chemokine structures the glycoprotein interferes with host antiviral defenses. It does not form part of a larger protein complex but acts individually to attract leukocytes to the site of infection potentially facilitating immune cell misdirection. This function helps the virus persist in the host and enhances its pathogenicity making the protein a target for anti-RSV strategies.

Pathways

RSV G glycoprotein operates in immune response modulation and viral entry pathways. It interacts with host cell pathways like the chemokine signaling pathway and is relevant to the viral exocytic pathway. Relations to other proteins occur as the glycoprotein's mimicry of chemokines affects the cytokine network. The G protein's action influences the regulation of immune-related proteins which can either promote or restrict infection via cellular signaling alterations.

The RSV G protein is closely connected to diseases such as bronchiolitis and pneumonia. These are common respiratory illnesses particularly in infants and the elderly influenced by RSV infection efficiency. The G glycoprotein's role in immune modulation exacerbates these conditions creating a link to proteins involved in respiratory inflammation such as cytokines and chemokines. Understanding the interplay with these proteins helps in the development of therapeutic strategies to manage RSV-induced respiratory diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform Membrane-bound glycoprotein G. Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection (PubMed : 10400758, PubMed : 10864656, PubMed : 3655746). Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection (PubMed : 11477410, PubMed : 26107373, PubMed : 26658574). Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (Probable).. Isoform Secreted glycoprotein G. Helps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.
See full target information G
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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

Journal of pharmaceutical analysis 15:101201 PubMed40735029

2025

Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia.

Applications

Unspecified application

Species

Unspecified reactive species

Chenqi Chang,Chang Lu,Yu Zheng,Lili Lin,XiuZhen Chen,Linwei Chen,Zhipeng Chen,Rui Chen

Viruses 16: PubMed39772241

2025

MARCH8 Restricts RSV Replication by Promoting Cellular Apoptosis Through Ubiquitin-Mediated Proteolysis of Viral SH Protein.

Applications

Unspecified application

Species

Unspecified reactive species

Takashi Okura,Tatsuki Takahashi,Taichi Kameya,Fuminori Mizukoshi,Yusuke Nakai,Masatoshi Kakizaki,Mayuko Nishi,Noriyuki Otsuki,Hirokazu Kimura,Kei Miyakawa,Kazuya Shirato,Wataru Kamitani,Akihide Ryo

Journal of virology 98:e0153624 PubMed39508604

2024

Both chebulagic acid and punicalagin inhibit respiratory syncytial virus entry via multi-targeting glycoprotein and fusion protein.

Applications

Unspecified application

Species

Unspecified reactive species

Yingcai Xiong,Keyu Tao,Tao Li,Yinghui Zhou,Zhaowei Zhang,Weiying Ou,Zhao Wang,Shouchuan Wang,Yayi Hou,Peng Cao,Jianjian Ji

iScience 27:111038 PubMed39474078

2024

The GDF6-FTO axis modulates the innate immune and inflammatory response to human respiratory syncytial virus.

Applications

Unspecified application

Species

Unspecified reactive species

Zhu Li,Ling Zhang,Yi Liu,Haitao Li,Ling Gong,Xinran Tan,Jiahua Tian,Hang Pi,Bingyao Wang,Yu Zhao,Daishun Liu

Frontiers in pharmacology 15:1410470 PubMed39035985

2024

Antiviral effect of alkaloids-free Ephedra Herb extract on respiratory syncytial virus infection.

Applications

Unspecified application

Species

Unspecified reactive species

Aya Fujikane,Ryosuke Fujikane,Sumiko Hyuga,Yusuke Sechi,Tetsuya Hiyoshi,Atsuhiko Sakamoto,Akinori Nishi,Hiroshi Odaguchi,Kenji Hiromatsu,Yukihiro Goda,Yoshizumi Ishino,Shigeki Nabeshima

Cellular and molecular life sciences : CMLS 81:267 PubMed38884678

2024

Virus neutralization assays for human respiratory syncytial virus using airway organoids.

Applications

Unspecified application

Species

Unspecified reactive species

Laura L A van Dijk,Laurine C Rijsbergen,Bruno Tello Rubio,Katharina S Schmitz,Lennert Gommers,Anouskha D Comvalius,Alexander Havelaar,Geert van Amerongen,Rutger Schepp,Mart M Lamers,Corine H GeurtsvanKessel,Bart L Haagmans,Rob van Binnendijk,Rik L de Swart,Rory D de Vries

PLoS pathogens 20:e1012198 PubMed38739647

2024

Intranasal respiratory syncytial virus vaccine attenuated by codon-pair deoptimization of seven open reading frames is genetically stable and elicits mucosal and systemic immunity and protection against challenge virus replication in hamsters.

Applications

Unspecified application

Species

Unspecified reactive species

Megan Levy,Jessica W Chen,Jaclyn A Kaiser,Hong-Su Park,Xueqiao Liu,Lijuan Yang,Celia Santos,Ursula J Buchholz,Cyril Le Nouën

Microbiology and immunology 67:413-421 PubMed37424190

2023

Establishment of a new reverse genetics system for respiratory syncytial virus under the control of RNA polymerase II.

Applications

Unspecified application

Species

Unspecified reactive species

Tatsuki Takahashi,Shiori Ueno,Yoshiro Sugiura,Kenta Shimizu,Wataru Kamitani

Viruses 13: PubMed33806073

2021

Inhibitory Effect of and Its Components on Replication of Respiratory Syncytial Virus In Vitro and In Vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Kiramage Chathuranga,Asela Weerawardhana,Niranjan Dodantenna,Lakmal Ranathunga,Won-Kyung Cho,Jin Yeul Ma,Jong-Soo Lee

Viruses 11: PubMed31277257

2019

Anti-Respiratory Syncytial Virus Activity of and Extracts In Vitro and In Vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Kiramage Chathuranga,Myun Soo Kim,Hyun-Cheol Lee,Tae-Hwan Kim,Jae-Hoon Kim,W A Gayan Chathuranga,Pathum Ekanayaka,H M S M Wijerathne,Won-Kyung Cho,Hong Ik Kim,Jin Yeul Ma,Jong-Soo Lee
View all publications
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