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Mouse Monoclonal SHMT1 antibody. Suitable for ELISA, WB, ICC/IF, IHC-Fr and reacts with Respiratory syncytial virus samples. Cited in 7 publications. Immunogen corresponding to Cell preparation containing Respiratory Syncytial Virus G Glycoprotein protein.

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Publications

Key facts

Isotype

IgG1

Host species

Mouse

Storage buffer

Preservative: 0.02% Sodium azide
Constituents: 99.98% PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Cell preparation containing Respiratory Syncytial Virus G Glycoprotein protein. The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
ELISAWBICC/IFIHC-Fr
Respiratory syncytial virus
Expected
Expected
Expected
Expected

Expected
Expected

Species

Respiratory syncytial virus

Dilution info

Use at an assay dependent concentration.

Notes

-

Expected
Expected

Species

Respiratory syncytial virus

Dilution info

Use at an assay dependent concentration.

Notes

-

Expected
Expected

Species

Respiratory syncytial virus

Dilution info

Use at an assay dependent concentration.

Notes

-

Expected
Expected

Species

Respiratory syncytial virus

Dilution info

-

Notes

Fix with Acetone.

Target data

Function

Isoform Membrane-bound glycoprotein GAttaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection (PubMed:10400758, PubMed:10864656, PubMed:3655746). Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection (PubMed:11477410, PubMed:26107373, PubMed:26658574). Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (Probable).Isoform Secreted glycoprotein GHelps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.

Alternative names

Recommended products

Mouse Monoclonal SHMT1 antibody. Suitable for ELISA, WB, ICC/IF, IHC-Fr and reacts with Respiratory syncytial virus samples. Cited in 7 publications. Immunogen corresponding to Cell preparation containing Respiratory Syncytial Virus G Glycoprotein protein.

Key facts

Isotype

IgG1

Form

Liquid

Clonality

Monoclonal

Immunogen
  • Cell preparation containing Respiratory Syncytial Virus G Glycoprotein protein. The exact immunogen used to generate this antibody is proprietary information.
Clone number

RSV133

Purification technique

Affinity purification Protein A

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Fusion partner: PS-NS/1-Ag4

ab94966 is useful for the identification and location of expression of the G glycoprotein of Human Respiratory Syncytial Virus (HRSV) of both sub-groups A and B . This antibody confers passive protection against HRSV of both subgroups in an animal model of hRSV infection.

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Respiratory Syncytial Virus G Glycoprotein also known as RSV G protein plays a significant mechanical role in the virus's lifecycle. This glycoprotein with a molecular mass of approximately 90 kDa is expressed on the surface of the Respiratory Syncytial Virus (RSV). RSV G protein primarily facilitates viral attachment to host cells by binding to heparan sulfate on the cell surface. This attachment serves as an initial step for viral infection aiding RSV in invading epithelial cells of the respiratory tract.

Biological function summary

The RSV G protein contributes to immune evasion and modulation within the host. By mimicking chemokine structures the glycoprotein interferes with host antiviral defenses. It does not form part of a larger protein complex but acts individually to attract leukocytes to the site of infection potentially facilitating immune cell misdirection. This function helps the virus persist in the host and enhances its pathogenicity making the protein a target for anti-RSV strategies.

Pathways

RSV G glycoprotein operates in immune response modulation and viral entry pathways. It interacts with host cell pathways like the chemokine signaling pathway and is relevant to the viral exocytic pathway. Relations to other proteins occur as the glycoprotein's mimicry of chemokines affects the cytokine network. The G protein's action influences the regulation of immune-related proteins which can either promote or restrict infection via cellular signaling alterations.

Associated diseases and disorders

The RSV G protein is closely connected to diseases such as bronchiolitis and pneumonia. These are common respiratory illnesses particularly in infants and the elderly influenced by RSV infection efficiency. The G glycoprotein's role in immune modulation exacerbates these conditions creating a link to proteins involved in respiratory inflammation such as cytokines and chemokines. Understanding the interplay with these proteins helps in the development of therapeutic strategies to manage RSV-induced respiratory diseases.

Product promise

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