Mouse Monoclonal SHMT1 antibody. Suitable for ELISA, WB, ICC/IF, IHC-Fr and reacts with Respiratory syncytial virus samples. Cited in 7 publications. Immunogen corresponding to Cell preparation containing Respiratory Syncytial Virus G Glycoprotein protein.
IgG1
Mouse
Preservative: 0.02% Sodium azide
Constituents: 99.98% PBS
Liquid
Monoclonal
ELISA | WB | ICC/IF | IHC-Fr | |
---|---|---|---|---|
Respiratory syncytial virus | Expected | Expected | Expected | Expected |
Species | Dilution info | Notes |
---|---|---|
Species Respiratory syncytial virus | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Respiratory syncytial virus | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Respiratory syncytial virus | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Respiratory syncytial virus | Dilution info - | Notes Fix with Acetone. |
Isoform Membrane-bound glycoprotein GAttaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection (PubMed:10400758, PubMed:10864656, PubMed:3655746). Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection (PubMed:11477410, PubMed:26107373, PubMed:26658574). Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (Probable).Isoform Secreted glycoprotein GHelps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.
Major surface glycoprotein G, Attachment glycoprotein G, Membrane-bound glycoprotein, mG, G
Mouse Monoclonal SHMT1 antibody. Suitable for ELISA, WB, ICC/IF, IHC-Fr and reacts with Respiratory syncytial virus samples. Cited in 7 publications. Immunogen corresponding to Cell preparation containing Respiratory Syncytial Virus G Glycoprotein protein.
IgG1
Mouse
Preservative: 0.02% Sodium azide
Constituents: 99.98% PBS
Liquid
Monoclonal
RSV133
Affinity purification Protein A
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Fusion partner: PS-NS/1-Ag4
ab94966 is useful for the identification and location of expression of the G glycoprotein of Human Respiratory Syncytial Virus (HRSV) of both sub-groups A and B . This antibody confers passive protection against HRSV of both subgroups in an animal model of hRSV infection.
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This supplementary information is collated from multiple sources and compiled automatically.
The Respiratory Syncytial Virus G Glycoprotein also known as RSV G protein plays a significant mechanical role in the virus's lifecycle. This glycoprotein with a molecular mass of approximately 90 kDa is expressed on the surface of the Respiratory Syncytial Virus (RSV). RSV G protein primarily facilitates viral attachment to host cells by binding to heparan sulfate on the cell surface. This attachment serves as an initial step for viral infection aiding RSV in invading epithelial cells of the respiratory tract.
The RSV G protein contributes to immune evasion and modulation within the host. By mimicking chemokine structures the glycoprotein interferes with host antiviral defenses. It does not form part of a larger protein complex but acts individually to attract leukocytes to the site of infection potentially facilitating immune cell misdirection. This function helps the virus persist in the host and enhances its pathogenicity making the protein a target for anti-RSV strategies.
RSV G glycoprotein operates in immune response modulation and viral entry pathways. It interacts with host cell pathways like the chemokine signaling pathway and is relevant to the viral exocytic pathway. Relations to other proteins occur as the glycoprotein's mimicry of chemokines affects the cytokine network. The G protein's action influences the regulation of immune-related proteins which can either promote or restrict infection via cellular signaling alterations.
The RSV G protein is closely connected to diseases such as bronchiolitis and pneumonia. These are common respiratory illnesses particularly in infants and the elderly influenced by RSV infection efficiency. The G glycoprotein's role in immune modulation exacerbates these conditions creating a link to proteins involved in respiratory inflammation such as cytokines and chemokines. Understanding the interplay with these proteins helps in the development of therapeutic strategies to manage RSV-induced respiratory diseases.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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