Anti-Respiratory Syncytial Virus Nucleoprotein antibody [RSV1C3] (ab94806) is a mouse monoclonal antibody that is used to detect Respiratory Syncytial Virus Nucleoprotein in IP, ICC/IF, ELISA. Suitable for Respiratory syncytial virus samples.
- Over 10 publications
- Trusted since 2010
Preservative: 0.02% Sodium azide
Constituents: 99.98% PBS
| IP | ELISA | ICC/IF | |
|---|---|---|---|
| Respiratory syncytial virus | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Respiratory syncytial virus | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Respiratory syncytial virus | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Respiratory syncytial virus | Dilution info - | Notes Acetone fixed |
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Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases (PubMed:19965480, PubMed:23677789, PubMed:31229488). RNA replication depends on the availability of soluble nucleoprotein (PubMed:22623798, PubMed:9299631). The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication (PubMed:22623798). Together with the phosphoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway (PubMed:32878896). May also act as a modulator of the innate immune response by sequestration of host IFIH1/MDA5 and MAVS into IBs (PubMed:22623778).
Nucleoprotein, Protein N, Nucleocapsid protein, N
Anti-Respiratory Syncytial Virus Nucleoprotein antibody [RSV1C3] (ab94806) is a mouse monoclonal antibody that is used to detect Respiratory Syncytial Virus Nucleoprotein in IP, ICC/IF, ELISA. Suitable for Respiratory syncytial virus samples.
- Over 10 publications
- Trusted since 2010
Preservative: 0.02% Sodium azide
Constituents: 99.98% PBS
This antibody has broad specificity for Human Respiratory syncytial virus of both sub groups A and B.
Respiratory Syncytial Virus Nucleoprotein (RSV N protein) plays a central mechanical role in the replication and transcription of the RSV genome. It binds single-stranded RNA acting as a scaffold for the virus's RNA synthesis. The nucleocapsid protein another name for RSV N protein has a molecular mass of approximately 45 kilodaltons. It is expressed in cells infected by the RSV notably within the cytoplasm forming a protective helix around the viral RNA genome.
Within the context of viral infection and replication RSV N protein is essential for packaging and protecting the viral RNA genome. It forms part of a complex with the phosphoprotein (P protein) and the large polymerase protein (L protein) to facilitate RNA replication and transcription. This complex ensures the stability and integrity of the viral genome allowing the virus to efficiently replicate and produce infectious particles. Therefore the nucleoprotein strongly influences the life cycle of the virus.
The RSV N protein functional capacity is pivotal within the viral RNA transcription and replication pathways. It closely interacts with the phosphoprotein P enhancing the activity of the viral RNA-dependent RNA polymerase complex. This interaction synergistically ties into the virus's replication pathway ensuring the production of viral RNAs. The N protein also coordinates with M2-1 protein in regulating mRNA synthesis and RNA processing reflecting its comprehensive involvement in essential viral pathways.
The involvement of RSV N protein connects strongly to respiratory tract infections particularly in infants and the elderly. RSV infection often leads to bronchiolitis and pneumonia where the N protein plays an important role in propagating the disease. Its interaction with the fusion glycoprotein (F protein) facilitates virus assembly and release which enhances viral spread and subsequent infection severity. Researchers often focus on these proteins when developing therapeutics targeting RSV-related diseases.
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