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AB94806

Anti-Respiratory Syncytial Virus Nucleoprotein antibody [RSV1C3]

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(14 Publications)

Anti-Respiratory Syncytial Virus Nucleoprotein antibody [RSV1C3] (ab94806) is a mouse monoclonal antibody detecting Respiratory Syncytial Virus Nucleoprotein in IP, ICC/IF, ELISA. Suitable for Respiratory syncytial virus.

- Over 10 publications
- Trusted since 2010

View Alternative Names

Nucleoprotein, Protein N, Nucleocapsid protein, N

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

RSV1C3

Isotype

IgG2a

Carrier free

No

Reacts with

Respiratory syncytial virus

Applications

IP, ICC/IF, ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

This antibody has broad specificity for Human Respiratory syncytial virus of both sub groups A and B.

Reactivity data

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Product details

What is this antibody validated in?
Anti-Respiratory Syncytial Virus Nucleoprotein antibody [RSV1C3] (ab94806) is a mouse monoclonal antibody and is validated for use in Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF), ELISA in Respiratory syncytial virus samples.

Trusted by the scientific community
Anti-Respiratory Syncytial Virus Nucleoprotein [RSV1C3] (ab94806) was first used in a scientific publication in 2010 and has been cited over 10 times in peer-reviewed journals.

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Respiratory Syncytial Virus Nucleoprotein (RSV N protein) plays a central mechanical role in the replication and transcription of the RSV genome. It binds single-stranded RNA acting as a scaffold for the virus's RNA synthesis. The nucleocapsid protein another name for RSV N protein has a molecular mass of approximately 45 kilodaltons. It is expressed in cells infected by the RSV notably within the cytoplasm forming a protective helix around the viral RNA genome.
Biological function summary

Within the context of viral infection and replication RSV N protein is essential for packaging and protecting the viral RNA genome. It forms part of a complex with the phosphoprotein (P protein) and the large polymerase protein (L protein) to facilitate RNA replication and transcription. This complex ensures the stability and integrity of the viral genome allowing the virus to efficiently replicate and produce infectious particles. Therefore the nucleoprotein strongly influences the life cycle of the virus.

Pathways

The RSV N protein functional capacity is pivotal within the viral RNA transcription and replication pathways. It closely interacts with the phosphoprotein P enhancing the activity of the viral RNA-dependent RNA polymerase complex. This interaction synergistically ties into the virus's replication pathway ensuring the production of viral RNAs. The N protein also coordinates with M2-1 protein in regulating mRNA synthesis and RNA processing reflecting its comprehensive involvement in essential viral pathways.

The involvement of RSV N protein connects strongly to respiratory tract infections particularly in infants and the elderly. RSV infection often leads to bronchiolitis and pneumonia where the N protein plays an important role in propagating the disease. Its interaction with the fusion glycoprotein (F protein) facilitates virus assembly and release which enhances viral spread and subsequent infection severity. Researchers often focus on these proteins when developing therapeutics targeting RSV-related diseases.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases (PubMed : 19965480, PubMed : 23677789, PubMed : 31229488). RNA replication depends on the availability of soluble nucleoprotein (PubMed : 22623798, PubMed : 9299631). The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication (PubMed : 22623798). Together with the phosphoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway (PubMed : 32878896). May also act as a modulator of the innate immune response by sequestration of host IFIH1/MDA5 and MAVS into IBs (PubMed : 22623778).
See full target information N

Publications (14)

Recent publications for all applications. Explore the full list and refine your search

Virology journal 22:244 PubMed40665364

2025

Respiratory syncytial virus (RSV) enhances translation of virus-resembling AU-rich host transcripts.

Applications

Unspecified application

Species

Unspecified reactive species

Kyra Kerkhofs,Nicholas R Guydosh,Mark A Bayfield

PLoS pathogens 20:e1012616 PubMed39413143

2024

8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in nucleoprotein-associated RNA of respiratory syncytial virus.

Applications

Unspecified application

Species

Unspecified reactive species

Lang Pan,Ke Wang,Wenjing Hao,Yaoyao Xue,Xu Zheng,Ritwika S Basu,Tapas K Hazra,Azharul Islam,Yashoda Hosakote,Bing Tian,Matthieu G Gagnon,Xueqing Ba,Istvan Boldogh

Viruses 16: PubMed38932114

2024

Respiratory Syncytial Virus Vaccine Design Using Structure-Based Machine-Learning Models.

Applications

Unspecified application

Species

Unspecified reactive species

Thomas C McCarty,Iosif I Vaisman

PLoS biology 21:e3002381 PubMed37983241

2023

Copy-back viral genomes induce a cellular stress response that interferes with viral protein expression without affecting antiviral immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Lavinia J González Aparicio,Yanling Yang,Matthew Hackbart,Carolina B López

Microbiology and immunology 67:413-421 PubMed37424190

2023

Establishment of a new reverse genetics system for respiratory syncytial virus under the control of RNA polymerase II.

Applications

Unspecified application

Species

Unspecified reactive species

Tatsuki Takahashi,Shiori Ueno,Yoshiro Sugiura,Kenta Shimizu,Wataru Kamitani

Virus research 327:199060 PubMed36746339

2023

RSV-induced expanded ciliated cells contribute to bronchial wall thickening.

Applications

Unspecified application

Species

Unspecified reactive species

Sattya N Talukdar,Jaspreet Osan,Ken Ryan,Bryon Grove,Danielle Perley,Bony D Kumar,Shirley Yang,Sydney Dallman,Lauren Hollingsworth,Kristina L Bailey,Masfique Mehedi

Cell reports 37:109803 PubMed34644581

2021

Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Jingjing Pei,Nina R Beri,Angela J Zou,Philipp Hubel,Hannah K Dorando,Valter Bergant,Rebecca D Andrews,Jiehong Pan,Jared M Andrews,Kathleen C F Sheehan,Andreas Pichlmair,Gaya K Amarasinghe,Steven L Brody,Jacqueline E Payton,Daisy W Leung

Journal of virology 95:e0056321 PubMed34011546

2021

Cyclophilin A Inhibits Human Respiratory Syncytial Virus (RSV) Replication by Binding to RSV-N through Its PPIase Activity.

Applications

Unspecified application

Species

Unspecified reactive species

Wenzhang Liang,Yue Zhang,Miao Li,Fadhl Al-Shaebi,Jian Li,Jing Zhang,Lin Wei

Journal of virology 94: PubMed32102886

2020

Long Noncoding RNA NRAV Promotes Respiratory Syncytial Virus Replication by Targeting the MicroRNA miR-509-3p/Rab5c Axis To Regulate Vesicle Transportation.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Li,Miao Li,Xiuli Wang,Mengfei Sun,Cuiqing Ma,Wenzhang Liang,Xue Gao,Lin Wei

PLoS pathogens 15:e1007963 PubMed31381610

2019

The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Matthias Lingemann,Thomas McCarty,Xueqiao Liu,Ursula J Buchholz,Sonja Surman,Scott E Martin,Peter L Collins,Shirin Munir
View all publications

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