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AB94967

Anti-Respiratory Syncytial Virus Subgroup A G Glycoprotein antibody [RSV1C2]

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(2 Publications)

Mouse Monoclonal SHMT1 antibody. Suitable for ELISA, WB, ICC/IF, IHC-Fr and reacts with Respiratory syncytial virus samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing Respiratory Syncytial Virus Subgroup A G Glycoprotein protein.

View Alternative Names

Major surface glycoprotein G, Attachment glycoprotein G, Membrane-bound glycoprotein, mG, G

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

RSV1C2

Isotype

IgG2a

Carrier free

No

Reacts with

Respiratory syncytial virus

Applications

ICC/IF, ELISA, IHC-Fr, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Respiratory syncytial virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Fix with Acetone.</p>" } } }
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Product details

Myeloma: PS-NS/1-Ag4

ab94967 is useful for the identification and location of subgroup A Respiratory Syncytial Virus G glycoprotein expression. This antibody confers passive protection against HRSV subgroup A in an animal model of Human Respiratory Syncytial Virus infection.
Recommended growth conditions: Growth medium RPMI with 25mM Hepes, 2mM additional glutamine and 10% heat inactivated foetal calf serum

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Respiratory Syncytial Virus Subgroup A G Glycoprotein often called RSV G protein is a surface protein responsible for viral attachment to host cells. It weighs approximately 90 kDa and expresses on the surface of RSV Subgroup A. The G glycoprotein interacts with heparan sulfate proteoglycans on the surface of epithelial cells facilitating virus entry into host cells. Its structure includes two major regions: a central conserved domain and an N-terminal region which contribute to its function in attachment and pathogenesis.
Biological function summary

This glycoprotein plays an important role in the virus's ability to evade the host immune response. It is not part of a larger complex but acts independently to modulate immune system pathways. It does so by interfering with the host's innate immune signaling reducing the effectiveness of the host's initial defense mechanisms. This enables the virus to establish infection efficiently and replicate within the host resulting in respiratory illness.

Pathways

The RSV G glycoprotein is involved in the manipulation of host cell signaling pathways related to immune response and inflammation. The protein affects signaling through pathways such as NF-kB which is important for regulating immune responses. It also associates with proteins such as CX3CR1 a receptor involved in leukocyte migration and inflammatory response. This association helps RSV in evading immune surveillance and establishing infection within the host.

The RSV G protein is significantly linked to respiratory illnesses such as bronchiolitis and pneumonia. These conditions are especially severe in infants and elderly populations. The G protein's interaction with the CX3CR1 receptor involved in leukocyte trafficking contributes to the inflammation and immune system disruption found in these diseases. Understanding these interactions can aid in developing therapies targeting RSV infections reducing the burden of associated respiratory diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform Membrane-bound glycoprotein G. Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection (PubMed : 10400758, PubMed : 10864656, PubMed : 3655746). Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection (PubMed : 11477410, PubMed : 26107373, PubMed : 26658574). Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (Probable).. Isoform Secreted glycoprotein G. Helps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.
See full target information G
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of pharmaceutical analysis 15:101201 PubMed40735029

2025

Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia.

Applications

Unspecified application

Species

Unspecified reactive species

Chenqi Chang,Chang Lu,Yu Zheng,Lili Lin,XiuZhen Chen,Linwei Chen,Zhipeng Chen,Rui Chen

Journal of virology 91: PubMed28747497

2017

Genetic Stability of Parainfluenza Virus 5-Vectored Human Respiratory Syncytial Virus Vaccine Candidates after and Passage.

Applications

Unspecified application

Species

Unspecified reactive species

Shannon I Phan,Carolyn M Adam,Zhenhai Chen,Michael Citron,Xiaoping Liang,Amy S Espeseth,Dai Wang,Biao He
View all publications
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