JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB317208

Anti-Respiratory Syncytial virus type A G protein antibody [HL2354]

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Monoclonal SHMT1 antibody. Suitable for WB and reacts with Human respiratory syncytial virus A (strain A2) samples. Immunogen corresponding to Recombinant Fragment Protein within Human respiratory syncytial virus A (strain A2) G.

View Alternative Names

Major surface glycoprotein G, Attachment glycoprotein G, Membrane-bound glycoprotein, mG, G

1 Images
Western blot - Anti-Respiratory Syncytial virus type A G protein antibody [HL2354] (AB317208)
  • WB

Supplier Data

Western blot - Anti-Respiratory Syncytial virus type A G protein antibody [HL2354] (AB317208)

Non-infected (–) and infected (+) HEp-2 whole cell extracts (5 ug) were separated by 12% SDS-PAGE and the membrane was blotted with ab317208 diluted at 1 : 1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody and the signal was developed with Trident ECL plus-Enhanced.

All lanes:

Western blot - Anti-Respiratory Syncytial virus type A G protein antibody [HL2354] (ab317208) at 1/1000 dilution

Lane 1:

Non-infected (–) HEp-2 whole cell extracts at 5 µg

Lane 2:

RSV type A infected (+) HEp-2 whole cell extracts at 5 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

true

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

HL2354

Isotype

IgG

Carrier free

No

Reacts with

Respiratory syncytial virus

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human respiratory syncytial virus A (strain A2) G.

P03423

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human respiratory syncytial virus A (strain A2)": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" }, "Respiratory syncytial virus": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Respiratory Syncytial Virus Subgroup A G Glycoprotein often called RSV G protein is a surface protein responsible for viral attachment to host cells. It weighs approximately 90 kDa and expresses on the surface of RSV Subgroup A. The G glycoprotein interacts with heparan sulfate proteoglycans on the surface of epithelial cells facilitating virus entry into host cells. Its structure includes two major regions: a central conserved domain and an N-terminal region which contribute to its function in attachment and pathogenesis.
Biological function summary

This glycoprotein plays an important role in the virus's ability to evade the host immune response. It is not part of a larger complex but acts independently to modulate immune system pathways. It does so by interfering with the host's innate immune signaling reducing the effectiveness of the host's initial defense mechanisms. This enables the virus to establish infection efficiently and replicate within the host resulting in respiratory illness.

Pathways

The RSV G glycoprotein is involved in the manipulation of host cell signaling pathways related to immune response and inflammation. The protein affects signaling through pathways such as NF-kB which is important for regulating immune responses. It also associates with proteins such as CX3CR1 a receptor involved in leukocyte migration and inflammatory response. This association helps RSV in evading immune surveillance and establishing infection within the host.

The RSV G protein is significantly linked to respiratory illnesses such as bronchiolitis and pneumonia. These conditions are especially severe in infants and elderly populations. The G protein's interaction with the CX3CR1 receptor involved in leukocyte trafficking contributes to the inflammation and immune system disruption found in these diseases. Understanding these interactions can aid in developing therapies targeting RSV infections reducing the burden of associated respiratory diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Isoform Membrane-bound glycoprotein G. Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection (PubMed : 10400758, PubMed : 10864656, PubMed : 3655746). Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection (PubMed : 11477410, PubMed : 26107373, PubMed : 26658574). Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (Probable).. Isoform Secreted glycoprotein G. Helps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.
See full target information G
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com