Anti-Reston virus Nucleoprotein antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Reston virus Nucleoprotein also known as Reston NP plays an essential role in the viral life cycle. It has a mass of approximately 75 kDa. This protein is found in cells infected by the Reston virus a member of the Filoviridae family which is part of the Ebola virus species. The nucleoprotein binds to the viral RNA genome forming a ribonucleoprotein complex that is involved in viral replication and packaging. This interaction is key for the virus to efficiently replicate and produce more viral particles inside the host cell.

Biological function summary

The Reston virus Nucleoprotein is involved in packaging the viral genome and interacts with other viral proteins to facilitate replication processes. The nucleoprotein associates with the viral polymerase complex which is needed for the synthesis of viral RNA. These associations are important for maintaining the structural stability of the viral capsid. Furthermore NP modulates the host immune response often by interfering with host antiviral defenses which helps the virus persist longer in host cells.

Pathways

The Reston virus Nucleoprotein operates within the viral replication and transcription pathways. The NP is involved in the encapsidation of the viral genome which is an important step in the formation of functional virions. It interacts with the viral polymerase L protein playing an important role in the transcription of viral messenger RNA. Such interactions are vital for initiating the transcription and replication mechanisms of the virus ensuring the viral genome's replication and spreading within an infected organism.

Associated diseases and disorders

The Reston virus Nucleoprotein is often associated with Reston virus hemorrhagic fever although this virus subtype shows low pathogenicity in humans compared to other Ebola strains. Nevertheless understanding its role is important to prevent potential cross-species transmission that may increase pathogenicity. The nucleoprotein also shares similarities with the nucleoproteins of other Ebola virus strains which are more pathogenic in humans. These connections underline the importance of NP in studies of viral pathogenicity and immune evasion aiding in the development of potential therapeutic and preventive strategies.