Rabbit Polyclonal RARG antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human RARG aa 1-100.
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Publications
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- iScience 17:74-862019Role of Retinoic Acid Receptor-γ in DNA Damage-Induced Necroptosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChamila Kadigamuwa et. al.PubMed 31255985
- Pediatric research 73:612-6202013Intrauterine growth restriction transiently delays alveolar formation and disrupts retinoic acid receptor expression in the lung of female rat pups.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLisa Joss-Moore et. al.PubMed 23419538
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human RARG aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link P13631
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Tested |
| Rat | Tested |
| Rabbit | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/2000 | Notes - |
Species Rat | Dilution info 1/2000 | Notes - |
Species Human | Dilution info 1/2000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rabbit | Dilution info - | Notes - |
Target data
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
Alternative names
NR1B3, RARG, Retinoic acid receptor gamma, RAR-gamma, Nuclear receptor subfamily 1 group B member 3
Recommended products
Rabbit Polyclonal RARG antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human RARG aa 1-100.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human RARG aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link P13631
- Purity
- Whole antiserum
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Retinoic Acid Receptor gamma 1 (RARG) functions as a nuclear receptor and transcription factor which means it binds to specific DNA sequences to regulate gene expression. Also known as RAR gamma this protein has a molecular mass of approximately 51 kDa. RARG is expressed in various tissues most notably in skin lung and the central nervous system. It acts by binding to retinoic acid a derivative of vitamin A which is essential for modulating cell differentiation and growth.
- Biological function summary
Retinoic Acid Receptor gamma 1 influences the regulation of several developmental processes and cellular homeostasis. The receptor operates often as part of a heterodimeric complex with the Retinoid X Receptor (RXR). This interaction is important for the receptor's ability to bind to retinoic acid response elements in DNA driving the expression of genes that control cell proliferation apoptosis and development. Its activity impacts skin keratinization and neural differentiation significantly.
- Pathways
Retinoic Acid Receptor gamma 1 is key in the retinoic acid signaling pathway which orchestrates the transcription of essential genes linked to cellular differentiation and organogenesis. RARG is closely related to other retinoic acid receptors like RAR alpha and RAR beta in this pathway. These receptors facilitate a network where retinoic acid acts as a ligand initiating changes in gene expression that affect cellular response and fate.
- Associated diseases and disorders
The dysregulation of RARG links to health issues such as skin disorders and certain types of cancer. Psoriasis for example involves abnormal proliferation and differentiation of keratinocytes where RARG may play a role alongside other proteins like RXR. In leukemia alterations in RARG have associations with disrupted differentiation of blood cell lines closely interacting with oncogenic fusion proteins. Understanding RARG's involvement in these conditions helps in developing targeted treatments.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Western blot - Anti-Retinoic Acid Receptor gamma 1 antibody (ab5904)
Detection: chemiluminescence.All lanes: Western blot - Anti-Retinoic Acid Receptor gamma 1 antibody (ab5904) at 1/500 dilution
Lane 1: MCF7 Nuclear enriched extract lysate at 50 µg
Lane 2: BeWo Nuclear enriched extract lysate at 50 µg
Lane 3: HaCaT Nuclear enriched extract lysate at 50 µg
Lane 4: HepG2 Nuclear enriched extract lysate at 50 µg
Lane 5: Mouse Mammary Gland tissue lysate at 50 µg
SecondaryAll lanes: Goat anti-Rabbit IgG (H+L) Superclonal™ Recombinant Secondary Antibody, HRP at 1/4000 dilution
Predicted band size: 50 kDa
Observed band size: 60 kDa
Western blot - Anti-Retinoic Acid Receptor gamma 1 antibody (ab5904)
All lanes: Western blot - Anti-Retinoic Acid Receptor gamma 1 antibody (ab5904)
Lane 1: HEK293 cell lysate with neutralizing peptide
Lane 2: HEK293 cell lysate
Predicted band size: 50 kDa
Western blot - Anti-Retinoic Acid Receptor gamma 1 antibody (ab5904)
Detection: chemiluminescence.All lanes: Western blot - Anti-Retinoic Acid Receptor gamma 1 antibody (ab5904) at 1/250 dilution
All lanes: Rat brain tissue lysate at 30 µg
SecondaryAll lanes: Goat anti-Rabbit IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate at 0.25 µg/mL
Predicted band size: 50 kDa
Observed band size: 42 kDa
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