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Rabbit Polyclonal RARG antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RARG aa 100-450.


Images

Western blot - Anti-Retinoic Acid Receptor gamma antibody (AB97569), expandable thumbnail
  • Western blot - Anti-Retinoic Acid Receptor gamma antibody (AB97569), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-Retinoic Acid Receptor gamma antibody (AB97569), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human RARG aa 100-450. The exact immunogen used to generate this antibody is proprietary information. Database link P13631

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBICC/IF
Human
Not recommended
Tested
Mouse
Not recommended
Predicted
Rat
Not recommended
Predicted
Cow
Not recommended
Predicted
Pig
Not recommended
Predicted
Zebrafish
Not recommended
Predicted

Not recommended
Not recommended

Species

Mouse, Human, Rat, Cow, Pig, Zebrafish

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/200.00000

Notes

-

Predicted
Predicted

Species

Mouse, Rat, Cow, Pig, Zebrafish

Dilution info

-

Notes

-

Associated Products

Select an associated product type

1 products for Alternative Product

Target data

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Alternative names

Recommended products

Rabbit Polyclonal RARG antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RARG aa 100-450.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human RARG aa 100-450. The exact immunogen used to generate this antibody is proprietary information. Database link P13631
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Retinoic Acid Receptor gamma (RARγ) also known as NR1B3 is a nuclear receptor that mediates the actions of retinoic acid. This receptor has a molecular mass of approximately 50 kDa. Scientists commonly find RARγ in a variety of tissues including the skin lung and central nervous system. The receptor functions as a transcription factor by binding to specific DNA sequences and regulating the expression of genes involved in cellular proliferation and differentiation.

Biological function summary

RARγ plays an essential role in modulating gene expression in response to retinoic acid. This receptor forms heterodimeric complexes with retinoid X receptors (RXRs) to initiate transcriptional activation. RARγ part of the nuclear receptor superfamily drives processes such as embryogenesis and cell differentiation by controlling gene networks. Its presence is necessary for proper functioning in many physiological contexts contributing to homeostasis and development.

Pathways

Retinoic acid signaling involves RARγ and plays a pivotal role in the retinoic acid signaling pathway and the Wnt signaling pathway. RARγ interacts with proteins like RXRs to regulate gene transcription necessary for cell fate decisions and tissue patterning. These pathways link to key cellular processes highlighting the importance of RARγ in transcriptional regulation and cellular development.

Associated diseases and disorders

RARγ has associations with skin disorders such as psoriasis and certain types of cancer including acute promyelocytic leukemia. Disruptions in retinoic acid signaling implicate this receptor in abnormal cell proliferation and differentiation. In leukemia the receptor partners with RXRs and interacts with fusion proteins like PML-RARα to drive cancerous processes. Understanding RARγ and its interactions contributes to developing treatments targeting these disease mechanisms.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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3 product images

  • Western blot - Anti-Retinoic Acid Receptor gamma antibody (ab97569), expandable thumbnail

    Western blot - Anti-Retinoic Acid Receptor gamma antibody (ab97569)

    10% SDS PAGE

    All lanes: Western blot - Anti-Retinoic Acid Receptor gamma antibody (ab97569) at 1/1000 dilution

    All lanes: NIH3T3 whole cell lysate at 30 µg

    Predicted band size: 50 kDa

  • Western blot - Anti-Retinoic Acid Receptor gamma antibody (ab97569), expandable thumbnail

    Western blot - Anti-Retinoic Acid Receptor gamma antibody (ab97569)

    7.5% SDS PAGE

    All lanes: Western blot - Anti-Retinoic Acid Receptor gamma antibody (ab97569) at 1/1000 dilution

    All lanes: Raji whole cell lysate at 30 µg

    Predicted band size: 50 kDa

  • Immunocytochemistry/ Immunofluorescence - Anti-Retinoic Acid Receptor gamma antibody (ab97569), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-Retinoic Acid Receptor gamma antibody (ab97569)

    ab97569, at a 1/200 dilution, staining Retinoic Acid Receptor gamma in paraformaldehyde-fixed HeLa cells, by Immunofluorescence analysis. Right image is merged with a DNA probe.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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