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AB221115

Anti-Retinoid X Receptor beta/RXRB antibody

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(3 Publications)

Rabbit Polyclonal Retinoid X Receptor beta/RXRB antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RXRB aa 50-100.

View Alternative Names

NR2B2, RXRB, Retinoic acid receptor RXR-beta, Nuclear receptor subfamily 2 group B member 2, Retinoid X receptor beta

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-Retinoid X Receptor beta/RXRB antibody (AB221115)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Retinoid X Receptor beta/RXRB antibody (AB221115)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized SK-MEL-30 cells labeling Retinoid X Receptor beta/RXRB with ab221115 at 4 μg/ml (green).

Western blot - Anti-Retinoid X Receptor beta/RXRB antibody (AB221115)
  • WB

Unknown

Western blot - Anti-Retinoid X Receptor beta/RXRB antibody (AB221115)

All lanes:

Western blot - Anti-Retinoid X Receptor beta/RXRB antibody (ab221115) at 1/100 dilution

Lane 1:

RT-4 cell lysate

Lane 2:

U-251 MG cell lysate

Lane 3:

Human plasma

Lane 4:

Human liver lysate

Lane 5:

Human tonsil lysate

Predicted band size: 57 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human RXRB aa 50-100. The exact immunogen used to generate this antibody is proprietary information.

P28702

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Alternative Products

Primary Antibodies

AB5793

Anti-Retinoid X Receptor beta/RXRB antibody

Western blot - Anti-Retinoid X Receptor beta/RXRB antibody (AB5793)

  • 5
  • 1

Complementary Products

Primary Antibodies

AB125001

Anti-Retinoid X Receptor alpha/RXRA antibody [EPR7106]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Retinoid X Receptor alpha/RXRA antibody [EPR7106] (AB125001)

  • 5
  • 5
Primary Antibodies

AB275745

Anti-Retinoic Acid Receptor alpha antibody [EPR23871-271]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Retinoic Acid Receptor alpha antibody [EPR23871-271] (AB275745)

  • 4
  • 1
Primary Antibodies

AB137634

Anti-CYP2R1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP2R1 antibody (AB137634)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/250", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Retinoid X Receptor Beta (RXRB) also known as NR2B2 is a nuclear receptor with a molecular mass of approximately 54 kDa. This receptor is widely expressed in various tissues including liver kidney and muscle. RXRB functions as a ligand-activated transcription factor meaning it regulates gene expression in response to binding with specific ligands. It partners with other nuclear receptors to form heterodimers allowing it to bind with high affinity to response elements in DNA regulating a wide variety of genes important for metabolic processes.
Biological function summary

RXRB contributes significantly to the regulation of gene networks by forming heterodimers with other nuclear receptors like PPARs (Peroxisome Proliferator-Activated Receptors) and LXR (Liver X Receptor). These complexes enable RXRB to exert control over diverse biological functions such as lipid metabolism glucose homeostasis and detoxification processes. RXRB influences these processes by modulating the expression of genes involved in the synthesis transport and metabolism of lipids and glucose important for maintaining metabolic homeostasis.

Pathways

RXRB plays an integral role in the retinoic acid signaling pathway and the nuclear receptor signaling pathway. In the retinoic acid pathway RXRB partners with Retinoic Acid Receptors (RARs) to regulate transcription of target genes important for cell differentiation and proliferation. Within the nuclear receptor signaling pathway RXRB frequently interacts with proteins such as PPARs and LXRs impacting lipid metabolism by influencing adipogenesis and cholesterol transport. These interactions underline RXRB's central position in managing metabolic pathways.

RXRB is linked to metabolic disorders including type 2 diabetes and dyslipidemia. Dysregulation of RXRB can lead to impaired lipid metabolism and insulin resistance impacting blood sugar and lipid profiles. The receptor interacts with PPARs in these conditions as they share regulatory roles in lipid and glucose metabolism. Additionally alterations in RXRB activity are linked to certain cancers with the receptor being part of pathways that regulate cell growth and differentiation. RXRB's role in these processes highlights its potential as a therapeutic target for managing metabolic diseases and cancer.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).
See full target information RXRB
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 42:113369 PubMed37922311

2023

Netrin-1 feedforward mechanism promotes pancreatic cancer liver metastasis via hepatic stellate cell activation, retinoid, and ELF3 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Crissy Dudgeon,Anthony Casabianca,Chris Harris,Charline Ogier,Mélanie Bellina,Stephany Fiore,Agnes Bernet,Benjamin Ducarouge,David Goldschneider,Xiaoyang Su,Jason Pitarresi,Aram Hezel,Subhajyoti De,Wade Narrow,Fady Soliman,Cory Shields,Debora Barbosa Vendramini-Costa,Orjola Prela,Lan Wang,Igor Astsaturov,Patrick Mehlen,Darren R Carpizo

Biochemical pharmacology 188:114559 PubMed33872571

2021

Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1α-dependent mitochondrial homeostasis in endothelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Zeng,Chun Yan Wang,Jin Xu,Xiao Le Xu

Cells 9: PubMed33238381

2020

LIMD2 Regulates Key Steps of Metastasis Cascade in Papillary Thyroid Cancer Cells via MAPK Crosstalk.

Applications

Unspecified application

Species

Unspecified reactive species

Rodrigo Pinheiro Araldi,Thatiana Correa de Melo,Débora Levy,Dener Madeiro de Souza,Beatriz Maurício,Gabriel Avelar Colozza-Gama,Sergio Paulo Bydlowski,Hongzhuang Peng,Frank J Rauscher,Janete Maria Cerutti
View all publications
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Product promise

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