Anti-Retinoid X Receptor beta/RXRB antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Retinoid X Receptor Beta (RXRB) also known as NR2B2 is a nuclear receptor with a molecular mass of approximately 54 kDa. This receptor is widely expressed in various tissues including liver kidney and muscle. RXRB functions as a ligand-activated transcription factor meaning it regulates gene expression in response to binding with specific ligands. It partners with other nuclear receptors to form heterodimers allowing it to bind with high affinity to response elements in DNA regulating a wide variety of genes important for metabolic processes.

Biological function summary

RXRB contributes significantly to the regulation of gene networks by forming heterodimers with other nuclear receptors like PPARs (Peroxisome Proliferator-Activated Receptors) and LXR (Liver X Receptor). These complexes enable RXRB to exert control over diverse biological functions such as lipid metabolism glucose homeostasis and detoxification processes. RXRB influences these processes by modulating the expression of genes involved in the synthesis transport and metabolism of lipids and glucose important for maintaining metabolic homeostasis.

Pathways

RXRB plays an integral role in the retinoic acid signaling pathway and the nuclear receptor signaling pathway. In the retinoic acid pathway RXRB partners with Retinoic Acid Receptors (RARs) to regulate transcription of target genes important for cell differentiation and proliferation. Within the nuclear receptor signaling pathway RXRB frequently interacts with proteins such as PPARs and LXRs impacting lipid metabolism by influencing adipogenesis and cholesterol transport. These interactions underline RXRB's central position in managing metabolic pathways.

Associated diseases and disorders

RXRB is linked to metabolic disorders including type 2 diabetes and dyslipidemia. Dysregulation of RXRB can lead to impaired lipid metabolism and insulin resistance impacting blood sugar and lipid profiles. The receptor interacts with PPARs in these conditions as they share regulatory roles in lipid and glucose metabolism. Additionally alterations in RXRB activity are linked to certain cancers with the receptor being part of pathways that regulate cell growth and differentiation. RXRB's role in these processes highlights its potential as a therapeutic target for managing metabolic diseases and cancer.