Anti-Retinoid X Receptor beta/RXRB antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

RXRB contributes significantly to the regulation of gene networks by forming heterodimers with other nuclear receptors like PPARs (Peroxisome Proliferator-Activated Receptors) and LXR (Liver X Receptor). These complexes enable RXRB to exert control over diverse biological functions such as lipid metabolism glucose homeostasis and detoxification processes. RXRB influences these processes by modulating the expression of genes involved in the synthesis transport and metabolism of lipids and glucose important for maintaining metabolic homeostasis.

Pathways

RXRB plays an integral role in the retinoic acid signaling pathway and the nuclear receptor signaling pathway. In the retinoic acid pathway RXRB partners with Retinoic Acid Receptors (RARs) to regulate transcription of target genes important for cell differentiation and proliferation. Within the nuclear receptor signaling pathway RXRB frequently interacts with proteins such as PPARs and LXRs impacting lipid metabolism by influencing adipogenesis and cholesterol transport. These interactions underline RXRB's central position in managing metabolic pathways.