JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB243536

Anti-REXO1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal REXO1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human REXO1 aa 200-350.

View Alternative Names

ELOABP1, KIAA1138, TCEB3BP1, REXO1, RNA exonuclease 1 homolog, Elongin-A-binding protein 1, Transcription elongation factor B polypeptide 3-binding protein 1, EloA-BP1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REXO1 antibody (AB243536)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REXO1 antibody (AB243536)

Formalin-fixed, paraffin-embedded human rectum tissue stained for REXO1 with ab243536 at a 1/200 dilution in immunohistochemical analysis.

Western blot - Anti-REXO1 antibody (AB243536)
  • WB

Supplier Data

Western blot - Anti-REXO1 antibody (AB243536)

All lanes:

Western blot - Anti-REXO1 antibody (ab243536) at 0.4 µg/mL

Lane 1:

RT4 (Human urinary bladder cancer cell line) cell lysate

Lane 2:

U-251 MG (Human brain glioma cell line) cell lysate

Lane 3:

Human plasma

Lane 4:

Human liver

Lane 5:

Human tonsil

Predicted band size: 132 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human REXO1 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

Q8N1G1

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

REXO1 also known as RNA exonuclease 1 homolog is a protein primarily involved in RNA processing. It functions mechanistically as an exonuclease which means it helps cut and process RNA molecules by removing nucleotides from the ends of RNA. This protein has an approximate molecular mass of 126 kDa. Researchers have identified REXO1 expression in various tissues but it is especially present in the testis and ovary indicating roles in reproductive tissue functions.
Biological function summary

REXO1 plays a significant role in maintaining RNA stability and regulating RNA quantity in cells. This protein does not operate alone; it is part of the exosome complex which is indispensable for RNA processing and degradation. Together with other proteins in the complex REXO1 contributes to the maturation of small RNAs and the degradation of defective mRNA molecules. By doing so the protein ensures the proper functioning of cellular RNA dynamics.

Pathways

REXO1 is involved in RNA degradation pathways and the processing of ribosomal RNA (rRNA). Within these pathways it collaborates closely with proteins such as DIS3 and EXOSC10 which are also components of the exosome. This cooperation facilitates the turnover and processing of RNA transcripts which is essential for gene expression regulation. REXO1's involvement in these pathways highlights its integral role in managing RNA homeostasis in cells.

REXO1 has connections to certain reproductive system disorders and cancers. Mutations or dysregulation of this protein can impact fertility potentially leading to conditions like infertility. Its relationship with other proteins such as components of the exosome complex indicates a broader impact on cellular function and genome stability. Furthermore REXO1 is often observed in cancerous cells where it may contribute to the altered RNA metabolism that characterizes many cancer types.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Seems to have no detectable effect on transcription elongation in vitro.
See full target information REXO1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer cell international 21:20 PubMed33407514

2021

Circ-CCDC66 upregulates REXO1 expression to aggravate cervical cancer progression via restraining miR-452-5p.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Zhang,Xing Li,Jun Zhang,Lin Mao
View all publications
style
left-column
style
left-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
style
left-column
style
right-column
style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com