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AB221098

Anti-RGC-32 antibody

5

(1 Review)

|

(4 Publications)

Rabbit Polyclonal RGC-32 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RGCC aa 1-100.

View Alternative Names

C13orf15, RGC32, RGCC, Regulator of cell cycle RGCC, Response gene to complement 32 protein, RGC-32

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-RGC-32 antibody (AB221098)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-RGC-32 antibody (AB221098)

Immunofluorescent analysis of paraformaldehyde-fixed, Triton X-100 permeabilized CACO-2 cells labeling RGC-32 with ab221098 at 4 μg/mL dilution (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human RGCC aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9H4X1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RGC-32 also known as response gene to complement 32 is a protein with a molecular weight of approximately 16 kDa. It acts as a cell cycle regulator and transcription coactivator. The protein influences cell division and apoptosis by interacting with other molecules in the cell. RGC-32 is strongly expressed in various tissues including the heart brain liver and kidneys. Its presence in many tissues suggests a widespread role in cellular processes beyond mere response to complement stimuli.
Biological function summary

RGC-32 contributes to cell cycle progression and differentiation. It does not act alone but collaborates with other proteins and enzymes to enable these processes. RGC-32 forms part of a complex that governs key steps in cell cycle regulation influencing cellular proliferation and differentiation pathways. Its involvement in these signaling cascades makes it essential for maintaining proper cell cycle control impacting cellular repair and growth.

Pathways

RGC-32 participates in the regulation of the TGF-β signaling pathway and the Wnt/β-catenin pathway. These two pathways are important for cellular growth differentiation and immune response. Within the TGF-β signaling pathway RGC-32 enhances the pathway's ability to mediate cell cycle arrest and fibrosis. In connection with the Wnt/β-catenin pathway RGC-32 modulates transcriptional activity that affects cell proliferation. The protein interacts with Smad proteins in TGF-β signaling forming part of the network that responds to growth factors.

RGC-32 is associated with conditions such as cancer and fibrosis. In cancer its overexpression or dysregulation may lead to uncontrolled cell proliferation and tumor development often through interactions with oncogenes and tumor suppressors. In fibrosis RGC-32 contributes to excessive extracellular matrix production playing a part in tissue scarring processes. The protein's interactions with TGF-β signaling are critical in fibrotic disorders while its connection with cyclin-dependent kinases links it potentially to oncogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.
See full target information RGCC
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

PloS one 20:e0328698 PubMed40720499

2025

Response Gene to Complement 32 promotes cell proliferation and tamoxifen resistance in breast cancer via elevated FoxM1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Xinlei Li,Yan Liu,Zhiqian Wang,Xiaocui Bu,Yu Wang,Wei Zhang,Peng Zhao

Translational oncology 52:102248 PubMed39709718

2024

Response Gene to Complement 32 is associated with poor patient survival and an inflamed tumor-immune microenvironment in clear cell renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Lingling Li,Xiaocui Bu,Shuhui Wang,Yan Liu,Chongdao Chen,Wei Zhang,Peng Zhao

Heliyon 10:e40405 PubMed39687103

2024

Establishment of prognostic risk model related to disulfidptosis and immune infiltration in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhe Xu,Chong Pang,Xundi Xu

Chemical research in toxicology 35:1533-1540 PubMed36074022

2022

Nonylphenol Promoted Epithelial-Mesenchymal Transition in Colorectal Cancer Cells by Upregulating the Expression of Regulator of Cell Cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Nian-Jie Zhang,Yuanwei Zhang,Shuo Yin,Du-Ji Ruan,Nian He,Xu Chen,Xue-Feng Yang
View all publications
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Product promise

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