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AB224465

Anti-RGD1310794 antibody

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(5 Publications)

Rabbit Polyclonal RGD1310794 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RBM48 aa 1-100.

View Alternative Names

C7orf64, HSPC304, RBM48, RNA-binding protein 48

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-RGD1310794 antibody (AB224465)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-RGD1310794 antibody (AB224465)

PFA-fixed/Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for RGD1310794 (green) using ab224465 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RGD1310794 antibody (AB224465)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RGD1310794 antibody (AB224465)

Paraffin-embedded human cerebral cortex tissue stained for RGD1310794 using ab224465 at 1/20 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human RBM48 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q5RL73

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RGD1310794 also known as Bcl-2-associated death promoter weighs around 23 kDa. This protein is expressed in various tissues throughout the body including the lymphatic tissues and the nervous system. Mechanically it promotes apoptosis by interacting with other proteins in the Bcl-2 family. Its expression increases in response to certain cellular stress signals aiding in the regulation of cell death processes.
Biological function summary

The protein plays a significant role in the apoptotic pathway as it is part of the pro-apoptotic complex. It enhances the release of cytochrome c from the mitochondria which is a critical step in apoptosis. When Bcl-2-associated death promoter forms complexes with Bax and Bak mitochondrial outer membrane permeabilization occurs. This function helps regulate cell populations and eliminates damaged or vulnerable cells.

Pathways

RGD1310794 is instrumental in the intrinsic apoptotic signaling pathway. It works closely with proteins such as Bax and Bak in mediating mitochondrial pathway activation. This pathway is essential for maintaining cellular homeostasis and is especially critical in tissue development and immune system balance.

Dysregulation of RGD1310794 activity is associated with cancer and neurodegenerative diseases. In cancer improper regulation of apoptosis can lead to uncontrolled cell growth making the apoptotic function of RGD1310794 highly relevant. In neurodegenerative conditions like Alzheimer's disease excessive apoptosis might contribute to neuronal loss. Proteins such as Bcl-2 which are known to oppose the action of RGD1310794 often play a role in the progression of these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
See full target information RBM48
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

eLife 13: PubMed40663059

2025

Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Dylan A Valencia,Angela N Koeberlein,Haruko Nakano,Akos Rudas,Aanand A Patel,Airi Harui,Cassandra Spencer,Atsushi Nakano,Margot E Quinlan

BioMed research international 2022:5068869 PubMed36225977

2022

A Novel Missense Variant: Expanding the Mutational Spectrum Associated with Nonsyndromic Low-Frequency Sensorineural Hearing Loss.

Applications

Unspecified application

Species

Unspecified reactive species

Jingyu Ma,Rongrong Wang,Li Zhang,Shanshan Wang,Shuqing Tong,Xiaohui Bai,Zhiming Lu

Scientific reports 12:4837 PubMed35319008

2022

Spidroin striped micropattern promotes chondrogenic differentiation of human Wharton's jelly mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Anggraini Barlian,Dinda Hani'ah Arum Saputri,Adriel Hernando,Candrani Khoirinaya,Ekavianty Prajatelistia,Hutomo Tanoto

Theranostics 11:64-78 PubMed33391461

2021

Extracellular-vesicles delivered tumor-specific sequential nanocatalysts can be used for MRI-informed nanocatalytic Therapy of hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Han Wu,Hao Xing,Meng-Chao Wu,Feng Shen,Yu Chen,Tian Yang

Scientific reports 10:19449 PubMed33173146

2020

Chondrogenic differentiation of Wharton's Jelly mesenchymal stem cells on silk spidroin-fibroin mix scaffold supplemented with L-ascorbic acid and platelet rich plasma.

Applications

Unspecified application

Species

Unspecified reactive species

Anggraini Barlian,Hermawan Judawisastra,Ahmad Ridwan,Antonia Ratih Wahyuni,Meidiana Ebtayani Lingga
View all publications
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