Anti-RGD1310794 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

RGD1310794 also known as Bcl-2-associated death promoter weighs around 23 kDa. This protein is expressed in various tissues throughout the body including the lymphatic tissues and the nervous system. Mechanically it promotes apoptosis by interacting with other proteins in the Bcl-2 family. Its expression increases in response to certain cellular stress signals aiding in the regulation of cell death processes.

Biological function summary

The protein plays a significant role in the apoptotic pathway as it is part of the pro-apoptotic complex. It enhances the release of cytochrome c from the mitochondria which is a critical step in apoptosis. When Bcl-2-associated death promoter forms complexes with Bax and Bak mitochondrial outer membrane permeabilization occurs. This function helps regulate cell populations and eliminates damaged or vulnerable cells.

Pathways

RGD1310794 is instrumental in the intrinsic apoptotic signaling pathway. It works closely with proteins such as Bax and Bak in mediating mitochondrial pathway activation. This pathway is essential for maintaining cellular homeostasis and is especially critical in tissue development and immune system balance.

Associated diseases and disorders

Dysregulation of RGD1310794 activity is associated with cancer and neurodegenerative diseases. In cancer improper regulation of apoptosis can lead to uncontrolled cell growth making the apoptotic function of RGD1310794 highly relevant. In neurodegenerative conditions like Alzheimer's disease excessive apoptosis might contribute to neuronal loss. Proteins such as Bcl-2 which are known to oppose the action of RGD1310794 often play a role in the progression of these diseases.