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AB137600

Anti-RGL2 antibody

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(2 Publications)

Rabbit Polyclonal RGL2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RGL2 aa 100-350.

View Alternative Names

RAB2L, RGL2, Ral guanine nucleotide dissociation stimulator-like 2, RalGDS-like 2, RalGDS-like factor, Ras-associated protein RAB2L

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-RGL2 antibody (AB137600)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-RGL2 antibody (AB137600)

Immunofluorescent analysis of paraformaldehyde-fixed HeLa cells labelling RGL2 with ab137600 at 1/200 dilution. Lower panel merged with DNA probe.

Western blot - Anti-RGL2 antibody (AB137600)
  • WB

Unknown

Western blot - Anti-RGL2 antibody (AB137600)

7.5% SDS PAGE

All lanes:

Western blot - Anti-RGL2 antibody (ab137600) at 1/500 dilution

All lanes:

Raji whole cell lysate at 30 µg

Predicted band size: 84 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human RGL2 aa 100-350. The exact immunogen used to generate this antibody is proprietary information.

O15211

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RGL2 also known as Ral Guanine Nucleotide Dissociation Stimulator-Like 2 is a protein that functions importantly in the regulation of small GTPases. It has a mass of approximately 109 kDa. RGL2 is expressed in various tissues but high levels are often present in the nervous tissue and the endocrine system. This expression pattern suggests its involvement in neuronal signaling and hormonal regulation.
Biological function summary

Ral Guanine Nucleotide Dissociation Stimulator-Like 2 acts as a guanine nucleotide exchange factor (GEF) which activates Ral GTPases by facilitating the exchange of GDP for GTP. The protein is a member of the RAS subfamily GEFs and contributes greatly to the formation of signaling complexes that affect multiple cellular processes. RGL2 interacts with other proteins to modulate cell growth cytoskeletal organization and vesicle trafficking.

Pathways

RGL2 plays a role in the MAPK/ERK signaling pathway and the PI3K/Akt pathway. These pathways are critical for cell proliferation and survival. It works closely with RalA and RalB proteins acting as a mediator in transmitting signals from receptor tyrosine kinases. Through this interaction RGL2 contributes to the regulation of cell cycle progression and apoptosis.

RGL2 has associations with cancer and neurodegenerative diseases. In some cancers upregulation of RGL2 leads to uncontrolled cellular proliferation where the protein interacts with other members of the Ras signaling pathway like c-Raf. Furthermore RGL2's role in neurodegenerative diseases is revealed by its impact on neuronal signaling potentially influencing conditions such as Alzheimer's disease through dysfunction in vesicular trafficking and synaptic plasticity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity).
See full target information RGL2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 12:858598 PubMed35321435

2022

Circular RNA circLMO1 Suppresses Cervical Cancer Growth and Metastasis by Triggering miR-4291/-Mediated Ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Rongying Ou,Shun Lu,Luhui Wang,Yebo Wang,Mingfen Lv,Tian Li,Yunsheng Xu,Jieqiang Lu,Ren-Shan Ge

The Journal of international medical research 48:300060519871407 PubMed32727237

2020

Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain.

Applications

Unspecified application

Species

Unspecified reactive species

Jue He,Yan Xu,Minhui Yi,Cancan Gu,Yi Zhu,Guohua Hu
View all publications
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Product promise

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