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AB113922

Anti-RGP1 antibody

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(1 Publication)

Rabbit Polyclonal RGP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RGP1.

View Alternative Names

KIAA0258, RGP1, RAB6A-GEF complex partner protein 2, Retrograde Golgi transport protein RGP1 homolog

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RGP1 antibody (AB113922)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RGP1 antibody (AB113922)

ab113922, at 5 μg/ml, staining RGP1 in formalin fixed, paraffin embedded Human kidney tissue by Immunohistochemistry.

Western blot - Anti-RGP1 antibody (AB113922)
  • WB

Unknown

Western blot - Anti-RGP1 antibody (AB113922)

Lane 1:

Western blot - Anti-RGP1 antibody (ab113922) at 1 µg/mL

Lane 2:

Western blot - Anti-RGP1 antibody (ab113922) at 2 µg/mL

All lanes:

Human heart tissue lysate

Predicted band size: 42 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human RGP1. The exact immunogen used to generate this antibody is proprietary information.

Q92546

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RGP1 also known as the RAB6A GTPase Activating Protein 1 is a protein involved in the activation of Rab GTPases particularly Rab6A. It has a molecular mass of approximately 46 kDa. RGP1 primarily expresses in the Golgi apparatus where it plays a role in membrane trafficking and vesicle transport. It acts as an important component in regulating the functionality of the Golgi complex which is essential for maintaining intracellular trafficking.
Biological function summary

The protein interacts with several other proteins and acts in a complex with RIC1. RGP1 plays an important role in tethering and fusion events during late Golgi transport. Its function modulates the movement of vesicles between the Golgi and endosome impacting cell transport processes significantly. The complex is necessary for maintaining the accuracy of cargo delivery and removal making it important for cellular homeostasis and normal cell growth.

Pathways

RGP1 serves a role in the retrograde transport pathway guiding the efficient movement of proteins from the Golgi back to the endoplasmic reticulum. The interaction with Rab6A and the complex with RIC1 enables RGP1 to manage this pathway effectively. Additionally RGP1 is part of the vesicle trafficking network further supported by its involvement with proteins such as BICD2 which impact cargo sorting and organelle positioning.

Deficiencies or abnormalities in RGP1 have links to neurological conditions like cerebral atrophy due to its involvement in intracellular trafficking. Disrupted Golgi function associated with malfunctioning RGP1 has connections with neurodegenerative diseases impacting proteins like Rab6A and their associated pathways. These disruptions underline its importance in cellular function and potential implications in disease etiology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.
See full target information RGP1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Poultry science 100:101342 PubMed34438327

2021

Effects of riboflavin deficiency on the lipid metabolism of duck breeders and duck embryos.

Applications

Unspecified application

Species

Unspecified reactive species

B Zhang,J Tang,Y B Wu,J T Cao,G N Xing,P X Sun,W Huang,M Xie,S S Hou
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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