Anti-RGP1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

RGP1 also known as the RAB6A GTPase Activating Protein 1 is a protein involved in the activation of Rab GTPases particularly Rab6A. It has a molecular mass of approximately 46 kDa. RGP1 primarily expresses in the Golgi apparatus where it plays a role in membrane trafficking and vesicle transport. It acts as an important component in regulating the functionality of the Golgi complex which is essential for maintaining intracellular trafficking.

Biological function summary

The protein interacts with several other proteins and acts in a complex with RIC1. RGP1 plays an important role in tethering and fusion events during late Golgi transport. Its function modulates the movement of vesicles between the Golgi and endosome impacting cell transport processes significantly. The complex is necessary for maintaining the accuracy of cargo delivery and removal making it important for cellular homeostasis and normal cell growth.

Pathways

RGP1 serves a role in the retrograde transport pathway guiding the efficient movement of proteins from the Golgi back to the endoplasmic reticulum. The interaction with Rab6A and the complex with RIC1 enables RGP1 to manage this pathway effectively. Additionally RGP1 is part of the vesicle trafficking network further supported by its involvement with proteins such as BICD2 which impact cargo sorting and organelle positioning.

Associated diseases and disorders

Deficiencies or abnormalities in RGP1 have links to neurological conditions like cerebral atrophy due to its involvement in intracellular trafficking. Disrupted Golgi function associated with malfunctioning RGP1 has connections with neurodegenerative diseases impacting proteins like Rab6A and their associated pathways. These disruptions underline its importance in cellular function and potential implications in disease etiology.