JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB154973

Anti-RGS1 antibody

Be the first to review this product! Submit a review

|

(4 Publications)

Rabbit Polyclonal RGS1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RGS1 aa 1 to C-terminus.

View Alternative Names

1R20, BL34, IER1, RGS1, Regulator of G-protein signaling 1, B-cell activation protein BL34, Early response protein 1R20

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RGS1 antibody (AB154973)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RGS1 antibody (AB154973)

Immunohistochemical analysis of paraffin-embedded Human Cal27 xenograft tissue labeling RGS1 with ab154973 at 1/500 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human RGS1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q08116

style
left-column

Alternative Products

Primary Antibodies

AB138015

Anti-RGS1 antibody

Western blot - Anti-RGS1 antibody (AB138015)

  • 0
  • 0
Primary Antibodies

AB117077

Anti-RGS1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RGS1 antibody (AB117077)

  • 0
  • 1

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
Primary Antibodies

AB32042

Anti-Cleaved Caspase-3 antibody [E83-77]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-Cleaved Caspase-3 antibody [E83-77] (AB32042)

  • 4
  • 28
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Regulator of G-protein signaling 1 (RGS1) also known as BL34 or 1R20 acts mechanically as a GTPase-activating protein (GAP) for Gα subunits of heterotrimeric G-proteins. This function speeds up the deactivation of G-proteins by converting GTP to GDP effectively stopping signal transduction. RGS1 has a molecular mass of approximately 25 kDa. This protein is mainly expressed in B and T lymphocytes and you can find it in lymphoid tissues such as the spleen and lymph nodes.
Biological function summary

The RGS1 protein modulates immune cell signaling thereby controlling cell migration and positioning. RGS1 plays a role in reducing signaling from chemokine receptors which affects the movement of lymphocytes within tissues. It does not significantly form part of a larger complex mostly acting independently to exert its function within the immune system.

Pathways

The regulatory activity of RGS1 heavily influences the chemokine signaling pathway and the G-protein coupled receptor (GPCR) signaling pathway. These pathways are important for the directional migration and activation of immune cells. Within these pathways RGS1 interacts with related proteins such as CXCR4 and Gα subunits modulating their signaling outputs to regulate immune cell responses.

RGS1 links to autoimmune diseases and certain cancers. It can modulate the immune response in diseases such as multiple sclerosis where its activity may affect immune cell movement and function. Connections also exist between RGS1 and CXCR4 within cancer pathology where altered signaling could contribute to tumor growth and metastasis. By affecting these pathways RGS1 becomes a potential target for therapeutic intervention in related disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed : 10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed : 10480894, PubMed : 18434541).
See full target information RGS1
style
left-column

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

EBioMedicine 108:105342 PubMed39321499

2024

Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics.

Applications

Unspecified application

Species

Unspecified reactive species

Zihao Mi,Zhenzhen Wang,Yi Wang,Xiaotong Xue,Xiaojie Liao,Chuan Wang,Lele Sun,Yingjie Lin,Jianwen Wang,Dianhao Guo,Tingting Liu,Jianjun Liu,Robert L Modlin,Hong Liu,Furen Zhang

Nature communications 15:2513 PubMed38514625

2024

Aberrant non-canonical NF-κB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel A Ang,Jean-Michel Carter,Kamalakshi Deka,Joel H L Tan,Jianbiao Zhou,Qingfeng Chen,Wee Joo Chng,Nathan Harmston,Yinghui Li

Acta pharmaceutica Sinica. B 13:598-617 PubMed36873185

2023

Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in -mutated acute myeloid leukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Yin Feng,Yefan Han,Anni Hu,Yi Qu,Yili Hu,Hao Wu,Xinzhi Wang,Li He

Annals of translational medicine 9:1652 PubMed34988161

2022

MicroRNA-376b-3p targets RGS1 mRNA to inhibit proliferation, metastasis, and apoptosis in osteosarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Zhang,Meng Yao,Weikang Ma,Yongqing Jiang,Wenbo Wang
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com