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AB229253

Anti-RGS19 antibody

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(1 Publication)

Rabbit Polyclonal RGS19 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RGS19.

View Alternative Names

GAIP, GNAI3IP, RGS19, Regulator of G-protein signaling 19, G-alpha-interacting protein

1 Images
Western blot - Anti-RGS19 antibody (AB229253)
  • WB

Supplier Data

Western blot - Anti-RGS19 antibody (AB229253)

12% SDS-PAGE

All lanes:

Western blot - Anti-RGS19 antibody (ab229253) at 1/10000 dilution

Lane 1:

HEK-293T whole cell lysate at 30 µg

Lane 2:

RGS19-transfected HEK-293T whole cell lysate at 30 µg

Predicted band size: 25 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human RGS19. The exact immunogen used to generate this antibody is proprietary information.

P49795

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000 - 1/20000", "WB-species-notes": "<p></p>" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RGS19 also known as regulator of G protein signaling 19 or GAIP (G Alpha Interacting Protein) is a member of the RGS family of proteins. It has a molecular weight of approximately 24 kDa. RGS19 primarily functions as a GTPase-activating protein (GAP) which accelerates the deactivation of G protein-coupled receptors (GPCRs) by increasing the rate of GTP hydrolysis on the alpha subunit of heterotrimeric G proteins. This regulatory protein primarily expresses in tissues like the brain lungs and heart where it plays a role in modulating signal transduction.
Biological function summary

The function of RGS19 plays an important role in controlling signal durations initiated by GPCRs. The protein is involved in the regulation of various signaling pathways that govern essential cellular processes such as cell differentiation and proliferation. RGS19 forms part of a larger complex with other cellular components where its interactions help modulate the intensity and duration of signals that influence cellular outcomes aiming at maintaining physiological balance.

Pathways

RGS19 integrates into pathways like the MAPK/ERK pathway and the cAMP signaling pathway. Within these pathways it modulates the activity by interacting with G alpha subunits impacting downstream signaling events. The protein is associated with proteins such as GNAI3 and GNAZ which further connects RGS19 to intricate networks of signaling molecules that ultimately regulate physiological functions.

Studies indicate RGS19 may be implicated in cancer and cardiovascular diseases. Aberrant regulation of RGS19 might influence cancer progression linking it to pathways that regulate cell growth and survival. Additionally it connects through its association with other proteins like GNAI3 where dysregulation can contribute to cardiovascular disease potentially affecting heart rhythm and function. Continual research focuses on understanding these associations to inform potential therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
See full target information RGS19
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Bioactive materials 53:737-753 PubMed40801020

2025

Inhibition of ARH2 by pH/ROS-responsive nanosystem for improved lung adenocarcinoma immunochemotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Cai,Meng Wang,Mengting Pan,Zhiwu Zhang,Qiang Jia,Longbao Feng,Zhongjian Yu,Lu Liu,Tongyu Zhu,Silin Cai,Han Tian,Jiangyu Zhang,Rui Guo,Yanfang Zheng
View all publications
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Product promise

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