Rabbit Polyclonal RGS20 antibody. Suitable for WB and reacts with Human, Rat, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human RGS20.
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- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 117:1091122019Regulator of G protein signaling 20 promotes proliferation and migration in bladder cancer via NF-κB signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGang Li,Meng Wang,Liangliang Ren,Hanzong Li,Qinghua Liu,Ying Ouyang,Lixin He,Fengyan LiPubMed 31212130
- Oncology reports 39:1948-19562018lncRNA NEAT1 promotes cell proliferation and invasion by regulating miR‑365/RGS20 in oral squamous cell carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGang Huang et. al.PubMed 29484420
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.1% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human RGS20. The exact immunogen used to generate this antibody is proprietary information. Database link O76081
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Tested |
| Rat | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 | Notes - |
Species Rat | Dilution info 1/500 | Notes - |
Species Mouse | Dilution info 1/500 | Notes - |
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Target data
Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
Alternative names
RGSZ1, ZGAP1, RGS20, Regulator of G-protein signaling 20, Gz-selective GTPase-activating protein, Regulator of G-protein signaling Z1, Regulator of Gz-selective protein signaling 1, G(z)GAP, Gz-GAP
Recommended products
Rabbit Polyclonal RGS20 antibody. Suitable for WB and reacts with Human, Rat, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human RGS20.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.1% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human RGS20. The exact immunogen used to generate this antibody is proprietary information. Database link O76081
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
ab191500 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen, and the purity is > 95% (by SDS-PAGE).
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
RGS20 also known as Regulator of G-protein Signaling 20 is a protein that functions mechanically as a GTPase-activating protein (GAP) for G-alpha subunits of heterotrimeric G proteins. It accelerates the termination of G-protein coupled receptor (GPCR) signaling pathways by increasing the GTPase activity of the G-alpha subunit. The protein has a molecular mass of approximately 26 kDa. RGS20 is expressed in various tissues with high levels in the brain and some expression in peripheral tissues such as the spleen and lung.
- Biological function summary
RGS20 modulates signal transduction by accelerating the deactivation of G-proteins which plays an important role in regulating GPCR signaling. It associates with G-beta and G-gamma forming a complex that allows for more efficient signal regulation. The activity of RGS20 is vital in neuronal signaling processes within the brain contributing to regulation of neurotransmitter release and synaptic plasticity.
- Pathways
RGS20 influences several G-protein mediated pathways such as the cAMP signaling pathway and the MAPK pathway. It interacts with the G-alpha subunits like G-alpha i and G-alpha q influencing the pathways' duration and intensity. RGS20's regulation of these pathways affects various cellular responses including cell growth and differentiation.
- Associated diseases and disorders
RGS20 relates to neurological disorders and cancer. Altered expression of RGS20 has been observed in some types of brain tumors and neurodegenerative diseases. It is associated with dopamine receptors that are implicated in disorders like schizophrenia and Parkinson's disease. Changes in RGS20 expression or function can affect signaling pathways related to these conditions making it an important protein for research in therapeutic targeting.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-RGS20 antibody (ab191500)
All lanes: Western blot - Anti-RGS20 antibody (ab191500) at 1/500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: NIH 3T3 whole cell lysate
Lane 3: H9C2 whole cell lysate
Predicted band size: 44 kDa
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