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AB239030

Anti-RGS20 antibody

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(1 Publication)

Rabbit Polyclonal RGS20 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RGS20 aa 1-250.

View Alternative Names

RGSZ1, ZGAP1, RGS20, Regulator of G-protein signaling 20, Gz-selective GTPase-activating protein, Regulator of G-protein signaling Z1, Regulator of Gz-selective protein signaling 1, G(z)GAP, Gz-GAP

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RGS20 antibody (AB239030)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RGS20 antibody (AB239030)

Paraffin-embedded human kidney tissue stained for RGS20 using ab239030 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-RGS20 antibody (AB239030)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-RGS20 antibody (AB239030)

A549 (Human lung carcinoma cell line) cells stained for RGS20 (Green) using ab239030 at 1/100 dilution in ICC/IF, followed by an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L) secondary antibody.

Western blot - Anti-RGS20 antibody (AB239030)
  • WB

Supplier Data

Western blot - Anti-RGS20 antibody (AB239030)

All lanes : ab239030 antibody at 8μg/ml + Mouse brain tissue lysate.

SecondaryGoat polyclonal to rabbit IgG at 1/10000 dilution.

Predicted band size : 44, 32, 22, 18, 26, 28 kDa.
Observed band size : 44 kDa.

All lanes:

Western blot - Anti-RGS20 antibody (ab239030)

Predicted band size: 44 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human RGS20 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

O76081

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RGS20 also known as Regulator of G-protein Signaling 20 is a protein that functions mechanically as a GTPase-activating protein (GAP) for G-alpha subunits of heterotrimeric G proteins. It accelerates the termination of G-protein coupled receptor (GPCR) signaling pathways by increasing the GTPase activity of the G-alpha subunit. The protein has a molecular mass of approximately 26 kDa. RGS20 is expressed in various tissues with high levels in the brain and some expression in peripheral tissues such as the spleen and lung.
Biological function summary

RGS20 modulates signal transduction by accelerating the deactivation of G-proteins which plays an important role in regulating GPCR signaling. It associates with G-beta and G-gamma forming a complex that allows for more efficient signal regulation. The activity of RGS20 is vital in neuronal signaling processes within the brain contributing to regulation of neurotransmitter release and synaptic plasticity.

Pathways

RGS20 influences several G-protein mediated pathways such as the cAMP signaling pathway and the MAPK pathway. It interacts with the G-alpha subunits like G-alpha i and G-alpha q influencing the pathways' duration and intensity. RGS20's regulation of these pathways affects various cellular responses including cell growth and differentiation.

RGS20 relates to neurological disorders and cancer. Altered expression of RGS20 has been observed in some types of brain tumors and neurodegenerative diseases. It is associated with dopamine receptors that are implicated in disorders like schizophrenia and Parkinson's disease. Changes in RGS20 expression or function can affect signaling pathways related to these conditions making it an important protein for research in therapeutic targeting.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
See full target information RGS20
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of Cancer 15:444-455 PubMed38169557

2024

CNKSR2 expression is correlated with immune infiltrates in Cervical Cancer as a favorable prognostic factor.

Applications

Unspecified application

Species

Unspecified reactive species

Guangxiao Li,Qiaoqiao Chen,Shihao Hong,Xiaoli Yang,Xiaoling Liang,Jianhua Yang
View all publications
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