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AB97307

Anti-RGS4 antibody

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(5 Publications)

Rabbit Polyclonal RGS4 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Regulator of G-protein signaling 4 aa 1-200.

View Alternative Names

Regulator of G-protein signaling 4, RGP4, RGS4

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RGS4 antibody (AB97307)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RGS4 antibody (AB97307)

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue staining RGS4 with ab97307 at 1 : 500 dilution.
Antigen Retrieval : EDTA based buffer, pH 8.0, 15min.

Western blot - Anti-RGS4 antibody (AB97307)
  • WB

Supplier Data

Western blot - Anti-RGS4 antibody (AB97307)

12% SDS-PAGE

All lanes:

Western blot - Anti-RGS4 antibody (ab97307) at 1/1000 dilution

All lanes:

Rat brain tissue extract at 50 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 23 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human Regulator of G-protein signaling 4 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

P49798

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Regulator of G-protein Signaling 4 (RGS4) also known as RGP4 belongs to the RGS family. It acts by accelerating the deactivation of G-proteins shortening the signal duration in G-protein-coupled receptor (GPCR) pathways. RGS4 has a molecular mass of approximately 26-28 kDa. The protein expresses in the central nervous system particularly the brain and in several peripheral tissues including heart and skeletal muscle.
Biological function summary

RGS proteins including RGS4 play an important role in modulating GPCR signaling by serving as GTPase-activating proteins (GAPs) for Gα subunits. RGS4 directly influences neurotransmission and signal transduction pathways by turning off G-protein activity affecting processes like mood regulation and cardiac function. Although RGS4 does not form part of a stable complex it dynamically interacts with G-proteins during signal transmission allowing it to impact various signaling pathways temporarily.

Pathways

Several signaling cascades depend on RGS4 for efficient function. It is closely involved in the MAPK signaling pathway which affects numerous cellular responses and the phosphatidylinositol signaling system which helps regulate intracellular calcium levels. These pathways link RGS4 to proteins such as Raf kinases and PLC-β which are key players in transducing signals from the cell surface to intracellular targets.

RGS4 has been associated with psychiatric and cardiac conditions. Schizophrenia connections appear in various studies where abnormal RGS4 expression potentially disrupts neurotransmitter signaling. Additionally RGS4 influences heart failure partly because of its role in modulating GPCR-mediated cardiac responses. It associates with proteins like Dopamine D2 receptors in schizophrenia and beta-adrenergic receptors in heart disorders indicating its potential impact in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
See full target information Regulator of G-protein signaling 4
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Chemical biology & drug design 105:e70075 PubMed40047202

2025

Ailanthone Restrains Osteosarcoma Growth and Metastasis by Decreasing the Expression of Regulator of G Protein Signaling 4 and Twist Family BHLH Transcription Factor 1.

Applications

Unspecified application

Species

Unspecified reactive species

Qiang Tan,Hongzhan Liu,Qiaojing Shi

Cancer letters 600:217180 PubMed39154702

2024

Single-cell RNA sequencing of OSCC primary tumors and lymph nodes reveals distinct origin and phenotype of fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Zhang,Liang Ding,Jingyi Li,Kunyu Liu,Chengwan Xia,Sheng Chen,Xiaofeng Huang,Yumei Pu,Yuxian Song,Qingang Hu,Yuxin Wang

Research in veterinary science 152:510-523 PubMed36174371

2022

NR3C1 and glucocorticoid-regulatory genes mRNA and protein expression in the endometrium and ampulla during the bovine estrous cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Mateo Ruiz-Conca,Jaume Gardela,Sergi Olvera-Maneu,Manel López-Béjar,Manuel Álvarez-Rodríguez

Molecular cancer research : MCR 19:1441-1453 PubMed34158395

2021

ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/β-Catenin Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Cong Xu,Yi-Ming Li,Bo Sun,Fang-Jing Zhong,Lian-Yue Yang

Oncology letters 18:5145-5154 PubMed31612026

2019

Mechanism of miR-107-targeting of regulator of G-protein signaling 4 in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Di Xiao,Hai-Xia Gao
View all publications
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Product promise

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