Anti-RGS4 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Regulator of G-protein Signaling 4 (RGS4) also known as RGP4 belongs to the RGS family. It acts by accelerating the deactivation of G-proteins shortening the signal duration in G-protein-coupled receptor (GPCR) pathways. RGS4 has a molecular mass of approximately 26-28 kDa. The protein expresses in the central nervous system particularly the brain and in several peripheral tissues including heart and skeletal muscle.

Biological function summary

RGS proteins including RGS4 play an important role in modulating GPCR signaling by serving as GTPase-activating proteins (GAPs) for Gα subunits. RGS4 directly influences neurotransmission and signal transduction pathways by turning off G-protein activity affecting processes like mood regulation and cardiac function. Although RGS4 does not form part of a stable complex it dynamically interacts with G-proteins during signal transmission allowing it to impact various signaling pathways temporarily.

Pathways

Several signaling cascades depend on RGS4 for efficient function. It is closely involved in the MAPK signaling pathway which affects numerous cellular responses and the phosphatidylinositol signaling system which helps regulate intracellular calcium levels. These pathways link RGS4 to proteins such as Raf kinases and PLC-β which are key players in transducing signals from the cell surface to intracellular targets.

Associated diseases and disorders

RGS4 has been associated with psychiatric and cardiac conditions. Schizophrenia connections appear in various studies where abnormal RGS4 expression potentially disrupts neurotransmitter signaling. Additionally RGS4 influences heart failure partly because of its role in modulating GPCR-mediated cardiac responses. It associates with proteins like Dopamine D2 receptors in schizophrenia and beta-adrenergic receptors in heart disorders indicating its potential impact in these conditions.