Rabbit Polyclonal RGS5 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human Regulator of G-protein signaling 5.
Images
Publications
Filter by
- Communications biology 6:9122023Single-cell transcriptomes reveal a molecular link between diabetic kidney and retinal lesions.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing Xu,Zhidan Xiang,Weigao E,Yue Lang,Sijia Huang,Weisong Qin,Jingping Yang,Zhaohong Chen,Zhihong LiuPubMed 37670124
- Frontiers in cell and developmental biology 10:9273002022Single-cell RNA sequencing reveals the cellular and molecular changes that contribute to the progression of lung adenocarcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBing Liu,Chen Wang,Zhanjie Fang,Jing Bai,Ying Qian,Yuanyuan Ma,Xiuyan Ruan,Shi Yan,Shaolei Li,Yaqi Wang,Bin Dong,Xin Yang,Meng Li,Xuefeng Xia,Hongzhu Qu,Xiangdong Fang,Nan WuPubMed 36046337
- BMC endocrine disorders 22:1562022Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXin Li,Yao Lu,Ling Zhang,Aiping Song,Honglei Zhang,Bo Pang,Jun Liu,Xiaoliang Sun,Haoyang Ji,Linping Huang,Meng YangPubMed 35681135
- PloS one 16:e02595582021NKX2-1 re-expression induces cell death through apoptosis and necrosis in dedifferentiated thyroid carcinoma cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuko Ito,Fumihiko Furuya,Katsumi Taki,Hideaki Suzuki,Hiroki ShimuraPubMed 34748583
- Cell discovery 7:362021Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYu Wang,Yiyi Liang,Haiyan Xu,Xiao Zhang,Tiebo Mao,Jiujie Cui,Jiayu Yao,Yongchao Wang,Feng Jiao,Xiuying Xiao,Jiong Hu,Qing Xia,Xiaofei Zhang,Xujun Wang,Yongwei Sun,Deliang Fu,Lei Shen,Xiaojiang Xu,Jing Xue,Liwei WangPubMed 34035226
- Cancer cell 39:866-882.e112021Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSilvia Affo,Ajay Nair,Francesco Brundu,Aashreya Ravichandra,Sonakshi Bhattacharjee,Michitaka Matsuda,LiKang Chin,Aveline Filliol,Wen Wen,Xinhua Song,Aubrianna Decker,Jeremy Worley,Jorge Matias Caviglia,Lexing Yu,Deqi Yin,Yoshinobu Saito,Thomas Savage,Rebecca G Wells,Matthias Mack,Lars Zender,Nicholas Arpaia,Helen E Remotti,Raul Rabadan,Peter Sims,Anne-Laure Leblond,Achim Weber,Marc-Oliver Riener,Brent R Stockwell,Jellert Gaublomme,Josep M Llovet,Raghu Kalluri,George K Michalopoulos,Ekihiro Seki,Daniela Sia,Xin Chen,Andrea Califano,Robert F SchwabePubMed 33930309
- Cell reports 29:1832-1847.e82019Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRoss Dobie,John R Wilson-Kanamori,Beth E P Henderson,James R Smith,Kylie P Matchett,Jordan R Portman,Karolina Wallenborg,Simone Picelli,Anna Zagorska,Swetha V Pendem,Thomas E Hudson,Minnie M Wu,Grant R Budas,David G Breckenridge,Ewen M Harrison,Damian J Mole,Stephen J Wigmore,Prakash Ramachandran,Chris P Ponting,Sarah A Teichmann,John C Marioni,Neil C HendersonPubMed 31722201
- Oncology reports 41:165-1772018RGS5 decreases the proliferation of human ovarian carcinoma‑derived primary endothelial cells through the MAPK/ERK signaling pathway in hypoxia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDan Wang,Yan Xu,Lu Feng,Pin Yin,Shuang Shuang Song,Feng Wu,Ping Yan,Zhiqing LiangPubMed 30365142
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human Regulator of G-protein signaling 5. The exact immunogen used to generate this antibody is proprietary information. Database link O15539
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Expected | Tested |
| Mouse | Tested | Expected |
| Rat | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/100.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).
Alternative names
Regulator of G-protein signaling 5, RGS5
Recommended products
Rabbit Polyclonal RGS5 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human Regulator of G-protein signaling 5.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human Regulator of G-protein signaling 5. The exact immunogen used to generate this antibody is proprietary information. Database link O15539
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Regulator of G-protein Signaling 5 (RGS5) also known as MSTP062 is a 20 kDa protein that modulates G-protein signaling. The protein acts by accelerating the GTPase activity of the alpha subunits of heterotrimeric G-proteins leading to the inactivation of G-protein-coupled receptor (GPCR) signaling. RGS5 shows high expression in vascular smooth muscle cells adipose tissue and the heart. The protein's localization indicates a role in the cardiovascular system and metabolism.
- Biological function summary
RGS5 regulates signal transduction pathways by acting as a negative regulator of GPCR signaling and influencing vascular tone and blood pressure. It forms part of the R4 subfamily of RGS proteins recognized for modulating G-protein activity. RGS5 impacts processes like vascular remodeling and angiogenesis by inhibiting G-protein-mediated signal transduction affecting the vascular cell response to proliferation and migration cues.
- Pathways
RGS5 plays a role in the GPCR signaling and the PI3K/AKT pathway. The protein interacts closely with G-protein alpha subunits such as Gαq and Gαi during the modulation of these pathways. This interaction helps regulate cardiovascular responses and cellular differentiation events coordinating with other RGS family members to maintain signaling balance.
- Associated diseases and disorders
RGS5 links with hypertension and cancer. In the context of hypertension altered expression of RGS5 correlates with vascular dysfunction affecting blood pressure regulation. In cancer RGS5 influences tumor angiogenesis and growth with potential interactions with proteins such as hypoxia-inducible factor 1-alpha (HIF-1α) affecting the oxygen supply to tumorous tissues. Understanding RGS5's involvement in these conditions can offer targets for therapeutic interventions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RGS5 antibody (ab196799)
Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded human breast carcinoma tissue sections labeling RGS5 with ab196799 at a 1/50 dilution. Right image treated with sythesized peptide.
Western blot - Anti-RGS5 antibody (ab196799)
All lanes: Western blot - Anti-RGS5 antibody (ab196799) at 1/500 dilution
Lane 1: Extracts from NIH/3T3 cells
Lane 2: Extracts from NIH/3T3 cells with synthesized peptide
Predicted band size: 21 kDa
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com