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AB155809

Anti-RGS6 antibody

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(2 Publications)

Rabbit Polyclonal RGS6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RGS6 aa 200-450.

View Alternative Names

Regulator of G-protein signaling 6, RGS6, S914

1 Images
Western blot - Anti-RGS6 antibody (AB155809)
  • WB

Unknown

Western blot - Anti-RGS6 antibody (AB155809)

10% SDS PAGE

All lanes:

Western blot - Anti-RGS6 antibody (ab155809) at 1/1000 dilution

All lanes:

PC3 whole cell lysate at 30 µg

Predicted band size: 54 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human RGS6 aa 200-450. The exact immunogen used to generate this antibody is proprietary information.

P49758

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Regulators of G-protein Signaling 6 (RGS6) is a multifunctional protein involved in the negative regulation of G-protein-coupled receptor signaling pathways. Commonly known as RGS6 this protein exhibits a mass of approximately 52 kDa. It is widely expressed in many tissues including the brain heart and liver. RGS6 contains a common RGS domain that accelerates the GTPase activity of G-alpha subunits facilitating the return of these subunits to their inactive GDP-bound form.
Biological function summary

RGS6 contributes to the fine-tuning of cellular signaling processes. It plays a significant role in nervous system function by modulating neurotransmitter release and signal transduction. RGS6 is part of a signaling complex that includes G-protein beta and gamma subunits which further refines its regulatory activity. This complex interaction helps to ensure precise control over timing and intensity of signal propagation in cells.

Pathways

RGS6 is an important component of the G-protein signaling pathway interacting with G-alpha subunits. It also has involvement in the MAPK/ERK signaling pathway where it influences cellular responses such as proliferation and differentiation. Related proteins in these pathways include other RGS family members and various MAP kinases that collaborate to maintain cellular homeostasis and response to environmental stimuli.

RGS6 has implications in conditions such as depression and cancer. It modulates pathways linked to these disorders for instance mood regulation and tumor proliferation. Through these functions RGS6 interacts with proteins like G-protein-coupled receptors and specific transcription factors associated with these diseases offering potential therapeutic targets for treatment.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed : 10521509).
See full target information RGS6
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Circulation research 125:379-397 PubMed31284824

2019

Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution.

Applications

Unspecified application

Species

Unspecified reactive species

William R Goodyer,Benjamin M Beyersdorf,David T Paik,Lei Tian,Guang Li,Jan W Buikema,Orlando Chirikian,Shannon Choi,Sneha Venkatraman,Eliza L Adams,Marc Tessier-Lavigne,Joseph C Wu,Sean M Wu

International journal of clinical and experimental 7:4120-7 PubMed25120791

2014

Decreased RGS6 expression is associated with poor prognosis in pancreatic cancer patients.

Applications

IHC

Species

Human

Nan Jiang,Ruihua Xue,Fangfang Bu,Xin Tong,Jiankun Qiang,Rong Liu
View all publications
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Product promise

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