Rabbit Polyclonal RHBDD1 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human RHBDD1 aa 1-150.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
ICC/IF | |
---|---|
Human | Tested |
Orangutan | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 0.25-2 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
Species | Dilution info | Notes |
---|---|---|
Species Orangutan | Dilution info - | Notes - |
Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia.
RHBDL4, HSD-50, HSD50, HSD50, HSD-50, RHBDL4, RHBDD1, Rhomboid-related protein 4, RRP4, Rhomboid domain-containing protein 1, Rhomboid-like protein 4
Rabbit Polyclonal RHBDD1 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human RHBDD1 aa 1-150.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
RHBDD1 also known as Rhomboid domain containing 1 is a type of rhomboid protease. It weighs about 54 kDa and mainly localizes in the membranes of cells. RHBDD1 exhibits proteolytic activity meaning it cuts specific substrate proteins. This function takes place within membranes predominantly in the endoplasmic reticulum and Golgi apparatus where it plays essential roles in regulated intramembrane proteolysis.
RHBDD1 participates in the regulation of several cellular processes such as apoptosis differentiation and protein quality control. This protease does not operate alone but functions not as a part of a larger protein complex. Instead it interacts with other proteins to facilitate cell adaptation to stress. RHBDD1's enzymatic activity influences the stability and turnover of certain proteins impacting the cell's ability to respond to environmental changes.
RHBDD1 integrates into cellular processes involving apoptosis and protein homeostasis regulation. It interacts with key proteins in the apoptosis pathway like BCL2-associated X (BAX) protein affecting cell death regulation. In the realm of protein homeostasis RHBDD1's activity complements chaperone proteins involved in maintaining proper protein folding and transport. The proper function of these pathways is critical for normal cellular function and adaptation to metabolic changes.
RHBDD1 has been connected with several types of cancer and neurodegenerative diseases. RHBDD1's interaction with apoptosis-related proteins like cancer-related p53 highlights its relevance in oncogenesis where abnormal regulation of apoptosis can lead to uncontrolled cell growth. Additionally neurodegenerative conditions where protein misfolding plays a role have shown links to RHBDD1 through its role in protein quality control pathways emphasizing its potential as a therapeutic target in these diseases.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U-2 OS cells labeling RHBDD1 with ab220855 at 4 μg/ml (green).
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