Skip to main content

Rabbit Polyclonal RHBDD1 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human RHBDD1 aa 1-150.

Be the first to review this product! Submit a review

Images

Immunocytochemistry/ Immunofluorescence - Anti-RHBDD1 antibody (AB220855), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human RHBDD1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TEB9

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
ICC/IF
Human
Tested
Orangutan
Predicted

Tested
Tested

Species

Human

Dilution info

0.25-2 µg/mL

Notes

Fixation/Permeabilization: PFA/Triton X-100.

Predicted
Predicted

Species

Orangutan

Dilution info

-

Notes

-

Target data

Function

Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia.

Alternative names

Recommended products

Rabbit Polyclonal RHBDD1 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human RHBDD1 aa 1-150.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human RHBDD1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TEB9
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

RHBDD1 also known as Rhomboid domain containing 1 is a type of rhomboid protease. It weighs about 54 kDa and mainly localizes in the membranes of cells. RHBDD1 exhibits proteolytic activity meaning it cuts specific substrate proteins. This function takes place within membranes predominantly in the endoplasmic reticulum and Golgi apparatus where it plays essential roles in regulated intramembrane proteolysis.

Biological function summary

RHBDD1 participates in the regulation of several cellular processes such as apoptosis differentiation and protein quality control. This protease does not operate alone but functions not as a part of a larger protein complex. Instead it interacts with other proteins to facilitate cell adaptation to stress. RHBDD1's enzymatic activity influences the stability and turnover of certain proteins impacting the cell's ability to respond to environmental changes.

Pathways

RHBDD1 integrates into cellular processes involving apoptosis and protein homeostasis regulation. It interacts with key proteins in the apoptosis pathway like BCL2-associated X (BAX) protein affecting cell death regulation. In the realm of protein homeostasis RHBDD1's activity complements chaperone proteins involved in maintaining proper protein folding and transport. The proper function of these pathways is critical for normal cellular function and adaptation to metabolic changes.

Associated diseases and disorders

RHBDD1 has been connected with several types of cancer and neurodegenerative diseases. RHBDD1's interaction with apoptosis-related proteins like cancer-related p53 highlights its relevance in oncogenesis where abnormal regulation of apoptosis can lead to uncontrolled cell growth. Additionally neurodegenerative conditions where protein misfolding plays a role have shown links to RHBDD1 through its role in protein quality control pathways emphasizing its potential as a therapeutic target in these diseases.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Immunocytochemistry/ Immunofluorescence - Anti-RHBDD1 antibody (ab220855), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-RHBDD1 antibody (ab220855)

    Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U-2 OS cells labeling RHBDD1 with ab220855 at 4 μg/ml (green).

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com