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AB106403

Anti-RHBDD2 antibody

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(1 Review)

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(1 Publication)

Rabbit Polyclonal RHBDD2 antibody. Suitable for WB, ICC/IF and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RHBDD2.

View Alternative Names

RHBDL7, RHBDD2, Rhomboid domain-containing protein 2

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-RHBDD2 antibody (AB106403)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-RHBDD2 antibody (AB106403)

Immunofluorescence of RHBDD2 in Rat Lung cells using ab106403 at 20 ug/ml.

Western blot - Anti-RHBDD2 antibody (AB106403)
  • WB

Unknown

Western blot - Anti-RHBDD2 antibody (AB106403)

Lane 1:

Western blot - Anti-RHBDD2 antibody (ab106403) at 1 µg/mL

Lane 2:

Western blot - Anti-RHBDD2 antibody (ab106403) at 2 µg/mL

All lanes:

Rat lung tissue lysate at 15 µg

Predicted band size: 39 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human RHBDD2. The exact immunogen used to generate this antibody is proprietary information.

Q6NTF9

Specificity

ab106403 is specific for RHBDD2 and will not cross-react with other RHBDD family members. At least four isoforms are known to exist.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RHBDD2 also known as rhomboid domain containing 2 is a serine protease that plays significant roles in intramembrane proteolysis. It has a molecular mass of approximately 44 kDa. This protein resides in the membranes of cellular endoplasmic reticulum and Golgi apparatus and it is expressed in various tissues including breast prostate and liver. RHBDD2 exhibits gene expression in both normal and cancerous cells suggesting its importance in physiological and pathological conditions.
Biological function summary

RHBDD2 participates in protein processing and quality control within the cell. It functions in the regulated intramembrane proteolysis of substrates impacting signaling pathways related to cell growth and apoptosis. Though RHBDD2 does not belong to a specific complex its proteolytic activity allows it to cleave and modulate activity of other membrane-associated proteins affecting their function and stability. This role positions RHBDD2 as an influential factor in determining protein fate within the cell.

Pathways

RHBDD2 embeds itself in the network of the ER-associated degradation (ERAD) pathway and the apoptosis signaling pathway. In the ERAD pathway RHBDD2 helps degrade misfolded proteins maintaining cellular homeostasis. In the apoptosis signaling pathway RHBDD2 indirectly influences through cleavage of proteins such as BCL2 family members integrating itself into pro-apoptotic and anti-apoptotic signals. Its connection with proteins like ubiquitin ligases in these pathways shows operation in cellular protein management.

RHBDD2 has associations with cancer and neurodegenerative disorders. Its overexpression in breast and prostate cancer implies a link with tumor growth and progression. In neurodegenerative conditions RHBDD2 expression can alter the processing of proteins like amyloid precursor protein (APP) impacting pathologies like Alzheimer's disease. These connections suggest that RHBDD2 along with its interacting molecules plays roles in cell proliferation and neurodegeneration processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information RHBDD2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 42:111949 PubMed36640307

2023

Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates.

Applications

Unspecified application

Species

Unspecified reactive species

Nathalie Scrima,Romain Le Bars,Quentin Nevers,Damien Glon,Guillaume Chevreux,Ahmet Civas,Danielle Blondel,Cécile Lagaudrière-Gesbert,Yves Gaudin
View all publications
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Product promise

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