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AB187904

Anti-RHCG antibody

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(2 Publications)

Rabbit Polyclonal RHCG antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RHCG aa 1-100.

View Alternative Names

C15orf6, CDRC2, PDRC2, RHGK, RHCG, Ammonium transporter Rh type C, Rh glycoprotein kidney, Rhesus blood group family type C glycoprotein, Tumor-related protein DRC2, Rh family type C glycoprotein, Rh type C glycoprotein

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHCG antibody (AB187904)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHCG antibody (AB187904)

Immunohistochemical analysis of paraffin embedded Human pancrease tissue (Negative control) using ab187904 at 1/1000 dilution showing no staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHCG antibody (AB187904)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHCG antibody (AB187904)

Immunohistochemical analysis showing RHCG staining in paraffin embedded Human kidney tissue using ab187904 at 1/1000 dilution showing positive staining in distal tubule cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHCG antibody (AB187904)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHCG antibody (AB187904)

Immunohistochemical analysis showing RHCG staining in paraffin embedded Human Esophagus tissue using ab187904 at 1/1000 dilution showing positive staining in squamous epithelial cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHCG antibody (AB187904)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHCG antibody (AB187904)

Immunohistochemical analysis showing RHCG staining in paraffin embedded Human tonsil tissue using ab187904 at 1/1000 dilution showing positive staining in squamous epithelial cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHCG antibody (AB187904)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHCG antibody (AB187904)

Immunohistochemical analysis of paraffin embedded Human lymph node tissue (Negative control) using ab187904 at 1/1000 dilution showing no staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human RHCG aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9UBD6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RHCG also known as Rhesus glycoprotein C is a transporter protein involved in the facilitation of ammonia and ammonium across cellular membranes. This protein has a molecular mass of approximately 50 kDa and it exhibits expression in tissues such as the kidney liver and skin. In the kidney particularly RHCG plays a significant role in the transport process associated with acid-base balance. Its function extends to the regulation of pH in body fluids which is fundamental for maintaining homeostasis.
Biological function summary

RHCG operates to maintain cellular and systemic homeostasis by participating in acid-base balance. It acts as part of a membrane transport mechanism contributing to the movement of ions across cell membranes. The protein does not form a complex but functions independently to transport ammonia an end-product of nitrogen metabolism. Its activity is important in epithelial cells where it assists in the secretion or reabsorption of ammonium playing a critical part in excretion processes in the renal and hepatic systems.

Pathways

There is a substantial significance of RHCG within the acid-base regulation pathway and nitrogen metabolism pathway. RHCG collaborates with other Rhesus proteins notably Rhesus glycoprotein B (RHBG) in these pathways. These pathways are integral to maintaining acid-base equilibrium and the excretion of excess nitrogen in the form of ammonium emphasizing its relevance in vital physiological processes.

RHCG associates with conditions concerning defective ammonium transport and acid-base imbalance. For example aberrations in RHCG function can contribute to metabolic acidosis or renal tubular acidosis. It displays potential interaction with the Rhesus glycoprotein family and may affect the regulation of pH levels in pathologic conditions. Dysregulation has implications in disease states where ammonia transport is compromised impacting the overall metabolic function and health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (PubMed : 11062476, PubMed : 14761968, PubMed : 15929723, PubMed : 16477434, PubMed : 16580862, PubMed : 24077989). May act as a CO2 channel providing for renal acid secretion (PubMed : 24077989).
See full target information RHCG
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Thoracic cancer 13:934-946 PubMed35307984

2022

CircATIC inhibits esophageal carcinoma progression and promotes radiosensitivity by elevating RHCG through sponging miR-10-3p.

Applications

Unspecified application

Species

Unspecified reactive species

Kai Zhang,Ruitai Fan,Deyao Zhao,Peipei Liu,Zheng Yang,Junqi Liu,Song Zhang,Shilei Rao,Yang Wang,Lixin Wan

Journal of experimental & clinical cancer research 38:244 PubMed31174563

2019

Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Nan Lin,Zhicheng Yao,Mingxing Xu,Jingyao Chen,Yi Lu,Lin Yuan,Shuqin Zhou,Xiaoguang Zou,Ruiyun Xu
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