Anti-RHOB antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

RHOB also known as Ras Homolog Family Member B is a small GTPase with a molecular mass of approximately 21 kDa. It acts as a molecular switch cycling between an active GTP-bound state and an inactive GDP-bound state. RHOB regulates various cellular functions including cytoskeletal organization and cell signaling. It is expressed in different human tissues with increased levels in the placenta lungs and testes.

Biological function summary

RHOB influences cell shape and motility by modulating actin architecture. It is part of the Rho GTPase family which impacts diverse cellular processes such as cell proliferation survival and vesicle trafficking. RHOB operates within protein complexes that contribute to its regulatory functions. It has an important role in controlling endosome dynamics and influences the signaling pathways that respond to environmental cues.

Pathways

By affecting cytoskeletal remodeling RHOB plays a role in the Rho signaling pathway. It interacts with related proteins like RHOA and CDC42 facilitating the coordination of these pathways. Additionally RHOB is involved in the integrin signaling pathway which impacts cell adhesion and migration processes. These pathways are significant for understanding how cells move and communicate in response to external stimuli.

Associated diseases and disorders

RHOB has implications in cancer development and progression. Aberrant expression or mutation of RHOB can correlate with tumor suppression or oncogenesis depending on the cellular context. It is associated with proteins such as AKT and PTEN which modulate cell survival and growth signals which are important in cancer biology. Furthermore RHOB shows involvement in cardiovascular diseases where it influences vascular remodeling processes through interactions with proteins like VEGFR2.