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AB204312

Anti-RHOC antibody

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(1 Publication)

Rabbit Polyclonal RHOC antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RHOC aa 100 to C-terminus.

View Alternative Names

ARH9, ARHC, RHOC, Rho-related GTP-binding protein RhoC, Rho cDNA clone 9, h9

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHOC antibody (AB204312)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHOC antibody (AB204312)

Immunohistochemical analysis of paraffin-embedded Human small intestine tissue, labeling RHOC using ab204312 at a 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human RHOC aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P08134

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RHOC also known as ras homolog family member C is a small GTPase with a molecular mass of approximately 22 kDa. This protein part of the Rho family is involved in various cellular functions including motility and mitosis. RHOC is widely expressed in different tissues but shows higher levels in certain tumor cells. Through its role in actin cytoskeleton organization RHOC mediates cellular structure and activity by binding to GDP and GTP molecules thereby controlling cell morphology and movement.
Biological function summary

RHOC influences cell migration invasion and proliferation key processes in cancer progression. It functions within the Rho family of GTPases interacting with other proteins like ROCK and mDia to regulate cytoskeletal dynamics. RHOC does not operate alone; it works as part of signaling complexes that affect cellular mechanisms such as adhesion and vesicle trafficking. Its activity modulates the balance between cell stability and movement making it significant in tissue remodeling and repair.

Pathways

RHOC plays pivotal roles in the Rho/ROCK and PI3K/Akt signaling pathways. Through these pathways it interacts with related GTPases like RHOA and RAC1. In the Rho/ROCK pathway RHOC influences actin cytoskeleton rearrangement impacting cell contractility and motility. Via the PI3K/Akt pathway RHOC is linked to cell survival and growth involving other proteins like PTEN and mTOR highlighting its function in integrating external signals for cellular response.

RHOC is relevant in cancer and cardiovascular diseases. In cancer elevated RHOC expression correlates with increased invasiveness and metastasis particularly in breast and pancreatic cancers. This association involves proteins such as integrins and cadherins which aid in cell adhesion and migration. RHOC is also implicated in cardiovascular disorders where abnormal cell migration and proliferation contribute to atherosclerosis. Understanding these interactions assists in potential targeting of RHOC for therapeutic purposes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.
See full target information RHOC
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Genetics in medicine open 2:100841 PubMed39669623

2023

Clinical study of ferredoxin-reductase-related mitochondriopathy: Genotype-phenotype correlation and proposal of ancestry-based carrier screening in the Mexican population.

Applications

Unspecified application

Species

Unspecified reactive species

Teresa Campbell,Jesse Slone,Hallie Metzger,Wensheng Liu,Stephanie Sacharow,Amy Yang,Mariya Moosajee,Chiara La Morgia,Valerio Carelli,Flavia Palombo,Matthew A Lines,A Micheil Innes,Rebecca J Levy,Derek Neilson,Nicola Longo,Taosheng Huang
View all publications
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Product promise

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