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AB185211

Anti-RHOD antibody [EPR7027] - N-terminal

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(1 Publication)

Rabbit Recombinant Monoclonal RHOD antibody. N-terminal. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

ARHD, RHOD, Rho-related GTP-binding protein RhoD, Rho-related protein HP1, RhoHP1

1 Images
Western blot - Anti-RHOD antibody [EPR7027] - N-terminal (AB185211)
  • WB

Supplier Data

Western blot - Anti-RHOD antibody [EPR7027] - N-terminal (AB185211)

All lanes:

Western blot - Anti-RHOD antibody [EPR7027] - N-terminal (ab185211) at 1/1000 dilution

All lanes:

Human fetal liver lysate at 20 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 23 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR7027

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RHOD also known as Rho-related GTP-binding protein RhoD is a small signaling GTPase and a member of the Rho family of proteins. It has an approximate mass of 21 kDa. This protein plays a mechanical role in the regulation of the actin cytoskeleton and vesicle trafficking within cells. Expression of RHOD is observed in various tissues with higher levels found in lung liver and brain tissues. RHOD interacts directly with other proteins to facilitate intracellular transport and actin dynamics.
Biological function summary

RHOD is involved in the rearrangement of the actin cytoskeleton and contributes to cellular processes like endosome transport and cell migration. It does not seem to function as part of a larger complex but has interactions with other Rho GTPase family members that influence cellular architecture and signal transduction. Through its role in modulating the cytoskeleton RHOD impacts cellular shape and mobility which are critical in diverse physiological contexts.

Pathways

The protein RHOD interacts with the pathways regulating the cytoskeleton and cell motility. Specifically RHOD is implicated in the Ras homolog family pathways that control actin polymerization and membrane trafficking. It links to other signaling molecules such as RHOB and RAC1 that are key players in these systems. RHOD’s function is essential for facilitating vesicular transport processes and ensuring proper cellular responses to extracellular signals.

RHOD has connections to cancer progression and neurological disorders. Studies indicate that RHOD dysregulation might contribute to tumorigenesis by altering cell motility and invasion capabilities. Moreover misregulated RHOD expression or function can impact nerve cell signaling and structure linking it to certain neuropathological conditions. It interacts with related proteins such as RHOC which are also involved in tumor cell dynamics further highlighting its significance in pathological contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.
See full target information RHOD
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cells 12: PubMed37296649

2023

Corneal Edema in Inducible Knockout Is Initiated by Mitochondrial Superoxide Induced Src Kinase Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Diego G Ogando,Edward T Kim,Shimin Li,Joseph A Bonanno
View all publications
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Product promise

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