Anti-Ricin toxin A chain antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

RTA participates in the toxic action of ricin which is a heterodimeric complex composed of the A chain and the B chain (RTB). RTB assists in binding and entry into host cells while RTA performs the disruptive enzymatic attack on the ribosomes. The severe effects of ricin toxicity depend largely on the function of RTA as it effectively stops cellular machinery leading to cell apoptosis. Understanding these interactions is important for comprehending the biological potential of RTA.

Pathways

RTA mainly impacts the pathway of protein synthesis in cells. Disruption occurs upon RTA's enzymatic cleavage of the rRNA from the ribosome inhibiting translation initiation and elongation phases in the cellular protein production line. While ricin acts mostly independently some proteins like elongation factors are indirectly affected by this pathway interference. RTA's role in the inhibition of protein synthesis pathways has been a subject of interest especially in studies of eukaryotic cell biology.