Rabbit Polyclonal RICS antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGAP32 aa 1950 to C-terminus.
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GRIT, KIAA0712, RICS, ARHGAP32, Rho GTPase-activating protein 32, Brain-specific Rho GTPase-activating protein, GAB-associated Cdc42/Rac GTPase-activating protein, GC-GAP, GTPase regulator interacting with TrkA, Rho-type GTPase-activating protein 32, Rho/Cdc42/Rac GTPase-activating protein RICS, RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling, p200RhoGAP, p250GAP
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RICS antibody (AB150847)
Immunohistochemical analysis of human small intestine tissue labeling RICS in the luminal membrane of glandular cells with ab1590847 at a 1/50 dilution.
Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-RICS antibody (AB150847)
Immunocytochemical analysis of HaCaT (Human keratinocyte cell line) whole cells labeling RICS in the nucleoplasm, nucleoli fibrillar center and Golgi apparatus with ab1590847 at 2 μg/ml.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RICS antibody (AB150847)
Immunohistochemical analysis of human skin tissue labeling RICS in the cytoplasm of squamous epithelial cells with ab1590847 at a 1/50 dilution.
Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RICS antibody (AB150847)
Immunohistochemical analysis of human liver tissue labeling RICS with ab1590847 at a 1/50 dilution. No positivity as expected.
Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RICS antibody (AB150847)
Immunohistochemical analysis of human cerebellum tissue labeling RICS in Purkinje cells with ab1590847 at a 1/50 dilution.
Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Biological function summary
RICS plays an important role in neuronal development and synaptic function. RICS is part of a protein complex that interacts with scaffolding proteins such as PSD-95 which is important for synaptic stability and plasticity. By modulating Rho GTPase activity RICS influences intracellular signaling which impacts cytoskeletal dynamics and receptor trafficking.
Pathways
RICS is involved in the regulation of signaling cascades such as the Wnt and Nogo pathways. It relates to proteins like Dishevelled in the Wnt pathway which regulates neuronal growth and differentiation. In the Nogo pathway RICS partners with proteins like Nogo receptor which limits axon regeneration and growth. These pathways illustrate how RICS modulates neuron structure and connectivity.
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Publications (1)
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The Journal of investigative dermatology 138:811-825 PubMed29391249
2018
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Species
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