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Mouse Recombinant Monoclonal RILPL1 antibody. Carrier free. Suitable for WB, ICC/IF, IP and reacts with Human, Mouse, Rat samples.

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Images

Western blot - Anti-RILPL1 antibody [MJF-R41-21] - Mouse IgG2a (Chimeric) - BSA and Azide free (AB307295), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-RILPL1 antibody [MJF-R41-21] - Mouse IgG2a (Chimeric) - BSA and Azide free (AB307295), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-RILPL1 antibody [MJF-R41-21] - Mouse IgG2a (Chimeric) - BSA and Azide free (AB307295), expandable thumbnail
  • Immunoprecipitation - Anti-RILPL1 antibody [MJF-R41-21] - Mouse IgG2a (Chimeric) - BSA and Azide free (AB307295), expandable thumbnail
  • Immunoprecipitation - Anti-RILPL1 antibody [MJF-R41-21] - Mouse IgG2a (Chimeric) - BSA and Azide free (AB307295), expandable thumbnail

Key facts

Isotype
IgG2a
Host species
Mouse
Storage buffer

pH: 7.2 - 7.4
Constituents: 100% PBS

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBICC/IFIP
Human
Tested
Tested
Tested
Mouse
Tested
Tested
Tested
Rat
Tested
Expected
Tested

Tested
Tested

Species
Human, Mouse, Rat
Dilution info
-
Notes

-

Tested
Tested

Species
Human, Mouse
Dilution info
-
Notes

-

Expected
Expected

Species
Rat
Dilution info
Use at an assay dependent concentration.
Notes

-

Tested
Tested

Species
Human, Mouse, Rat
Dilution info
-
Notes

-

Associated Products

Select an associated product type

3 products for Alternative Version

Target data

Function

Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (PubMed:14668488). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (PubMed:30398148).

Alternative names

RLP1, RILPL1, RILP-like protein 1, Rab-interacting lysosomal-like protein 1

Recommended products

Mouse Recombinant Monoclonal RILPL1 antibody. Carrier free. Suitable for WB, ICC/IF, IP and reacts with Human, Mouse, Rat samples.

Key facts

Isotype
IgG2a
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Carrier free
Yes
Clone number
MJF-R41-21
Purification technique
Affinity purification Protein A
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze

Notes

ab307295 is a carrier free version of Anti-RILPL1 antibody [MJF-R41-21] - Mouse IgG2a (Chimeric) ab307294.

This mouse monoclonal chimeric antibody has been engineered from a RabMAb parent antibody (Anti-RILPL1 antibody [MJF-R41-21] ab302492). By necessity, some rabbit sequence is retained as part of the variable domain. When multiplexing with other rabbit-derived antibodies, using cross absorbed FC-reactive secondary antibodies are recommended.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.

This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

RILPL1 also known as Rab interacting lysosomal protein-like 1 is a protein involved in cellular processes related to lysosomal trafficking. It has a molecular weight of approximately 45 kDa. RILPL1 expresses itself in a variety of tissues notably in the brain. The protein plays a significant role in intracellular transport mechanisms specifically in modulating the interaction between lysosomal structures and other cellular components.

Biological function summary

RILPL1 influences neuronal functions and is implicated in the regulation of ciliogenesis and other cellular morphogenesis processes. It often associates with components of the cytoskeletal network acting within protein complexes that contribute to cell shape and stability. This involves aiding in processes like axon transport which is critical for maintaining neuronal connectivity and function across different regions of the brain.

Pathways

RILPL1 is a part of cellular pathways involving lysosome positioning and transport. It interacts with motor proteins such as dynein and kinesin essential for microtubule-based movement. RILPL1's role in these pathways highlights its contribution to maintaining lysosomal homeostasis and transportation impacting processes like autophagy and endocytosis.

Associated diseases and disorders

RILPL1 has been linked to neurodegenerative diseases like Huntington’s disease where disruption of lysosomal trafficking can lead to cellular pathology. The protein's interaction with the Huntingtin protein suggests its involvement in pathways that when dysregulated contribute to disease progression. Additionally irregularities in RILPL1 function may relate to ciliopathies disorders affecting cilia formation and function due to its role in driving key processes in neuronal cells.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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