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AB69860

Anti-RIM2 antibody

2

(1 Review)

|

(1 Publication)

Rabbit Polyclonal RIM2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication.

View Alternative Names

KIAA0751, RAB3IP3, RIM2, RIMS2, Regulating synaptic membrane exocytosis protein 2, Rab-3-interacting molecule 2, Rab-3-interacting protein 3, RIM 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RIM2 antibody (AB69860)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RIM2 antibody (AB69860)

ab69860 at 5 μg/ml staining RIM2 in human prostate tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

Western blot - Anti-RIM2 antibody (AB69860)
  • WB

Supplier Data

Western blot - Anti-RIM2 antibody (AB69860)

All lanes:

Western blot - Anti-RIM2 antibody (ab69860) at 1 µg/mL

All lanes:

Human brain lysates

Predicted band size: 160 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human RIMS2. The exact immunogen used to generate this antibody is proprietary information.

Q9UQ26

Specificity

RIM2 is known to exist in multiple isoforms; this antibody should recognize most of them. The antibody is predicted to have no cross reactivity to other RIM proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFoFr" : {"fullname" : "Immunohistochemistry (PFA perfusion fixed frozen sections)", "shortname":"IHC-FoFr"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "IHCFoFr-species-checked": "notRecommended", "IHCFoFr-species-dilution-info": "", "IHCFoFr-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RIM2 also known as Rab3-interacting molecule 2 is a protein that facilitates synaptic vesicle priming. It acts as an important component in the release of neurotransmitters at synaptic junctions. The RIM2 protein has a molecular weight of approximately 150 kDa. Researchers often find it expressed in neuronal tissues where it plays an important role in neurotransmitter release.
Biological function summary

RIM2 interacts with other proteins to form a complex that stabilizes synaptic transmission. This protein complex is essential for the regulation of neurotransmitter release maintaining synaptic vesicle docking and priming processes. RIM2 facilitates a balance in the presynaptic terminal influencing the effective throughput of signals between neurons. Its precise location in nerve cells allows it to function efficiently in the rapid and controlled release of neurotransmitters.

Pathways

RIM2 plays a critical role in the regulation of the synaptic vesicle cycle and neurotransmitter release pathways. It often interacts with proteins such as Munc13 and synaptotagmin which are important in the synaptic vesicle fusion process. Through this involvement RIM2 contributes to the proper function of synaptic signaling and communication within the nervous system.

Studies link RIM2 dysregulation to neurological disorders like epilepsy and autism spectrum disorder. The disruption of its interaction with proteins such as Rab3 can lead to impaired synaptic function and subsequent neurological symptoms. Understanding RIM2's role offers insights into therapeutic approaches for treating associated neurological disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed : 23999003).
See full target information RIMS2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Endocrinology 153:574-82 PubMed22147008

2011

Glucagon-like peptide-1 enhances glucokinase activity in pancreatic β-cells through the association of Epac2 with Rim2 and Rab3A.

Applications

WB

Species

Human

Jae-Hyung Park,Sun-Joo Kim,Sung-Hee Park,Dae-Gu Son,Jae-Hoon Bae,Hyoung Kyu Kim,Jin Han,Dae-Kyu Song
View all publications
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Product promise

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