Rabbit Polyclonal RIM2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RIMS2.
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Publications
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- Endocrinology 153:574-822011Glucagon-like peptide-1 enhances glucokinase activity in pancreatic β-cells through the association of Epac2 with Rim2 and Rab3A.Applications:WBReactive species:HumanJae-Hyung Park,Sun-Joo Kim,Sung-Hee Park,Dae-Gu Son,Jae-Hoon Bae,Hyoung Kyu Kim,Jin Han,Dae-Kyu SongPubMed 22147008
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human RIMS2. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UQ26
Reactivity data
Select an application| WB | IHC-FoFr | IHC-P | |
|---|---|---|---|
| Human | Tested | Not recommended | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
IHC-FoFr
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5 µg/mL | Notes - |
Target data
Function
Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Alternative names
KIAA0751, RAB3IP3, RIM2, RIMS2, Regulating synaptic membrane exocytosis protein 2, Rab-3-interacting molecule 2, Rab-3-interacting protein 3, RIM 2
Recommended products
Rabbit Polyclonal RIM2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RIMS2.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human RIMS2. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UQ26
- Purification technique
- Affinity purification Immunogen
- Specificity
RIM2 is known to exist in multiple isoforms; this antibody should recognize most of them. The antibody is predicted to have no cross reactivity to other RIM proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
RIM2 also known as Rab3-interacting molecule 2 is a protein that facilitates synaptic vesicle priming. It acts as an important component in the release of neurotransmitters at synaptic junctions. The RIM2 protein has a molecular weight of approximately 150 kDa. Researchers often find it expressed in neuronal tissues where it plays an important role in neurotransmitter release.
- Biological function summary
RIM2 interacts with other proteins to form a complex that stabilizes synaptic transmission. This protein complex is essential for the regulation of neurotransmitter release maintaining synaptic vesicle docking and priming processes. RIM2 facilitates a balance in the presynaptic terminal influencing the effective throughput of signals between neurons. Its precise location in nerve cells allows it to function efficiently in the rapid and controlled release of neurotransmitters.
- Pathways
RIM2 plays a critical role in the regulation of the synaptic vesicle cycle and neurotransmitter release pathways. It often interacts with proteins such as Munc13 and synaptotagmin which are important in the synaptic vesicle fusion process. Through this involvement RIM2 contributes to the proper function of synaptic signaling and communication within the nervous system.
- Associated diseases and disorders
Studies link RIM2 dysregulation to neurological disorders like epilepsy and autism spectrum disorder. The disruption of its interaction with proteins such as Rab3 can lead to impaired synaptic function and subsequent neurological symptoms. Understanding RIM2's role offers insights into therapeutic approaches for treating associated neurological disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-RIM2 antibody (ab69860)
All lanes: Western blot - Anti-RIM2 antibody (ab69860) at 1 µg/mL
All lanes: Human brain lysates
Predicted band size: 160 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RIM2 antibody (ab69860)
ab69860 at 5 μg/ml staining RIM2 in human prostate tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).
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