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AB192602

Anti-RIMS3 antibody [EPR10117(2)]

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(1 Publication)

Rabbit Recombinant Monoclonal RIMS3 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.

View Alternative Names

KIAA0237, RIMS3, Regulating synaptic membrane exocytosis protein 3, Nim3, RIM3 gamma, Rab-3-interacting molecule 3, RIM 3

2 Images
Western blot - Anti-RIMS3 antibody [EPR10117(2)] (AB192602)
  • WB

Supplier Data

Western blot - Anti-RIMS3 antibody [EPR10117(2)] (AB192602)

All lanes:

Western blot - Anti-RIMS3 antibody [EPR10117(2)] (ab192602) at 1/10000 dilution

Lane 1:

Human cerebellum lysate at 20 µg

Lane 2:

Human fetal brain lysate at 20 µg

Secondary

All lanes:

goat anti-rabbit IgG, (H+L), peroxidase conjugated at 1/1000 dilution

Predicted band size: 33 kDa

Observed band size: 40 kDa

true

Western blot - Anti-RIMS3 antibody [EPR10117(2)] (AB192602)
  • WB

Supplier Data

Western blot - Anti-RIMS3 antibody [EPR10117(2)] (AB192602)

It is not sure that if the band at about 30 kDa is the extra band.

All lanes:

Western blot - Anti-RIMS3 antibody [EPR10117(2)] (ab192602) at 1/1000 dilution

Lane 1:

mouse brain lysate at 10 µg

Lane 2:

rat brain lysate at 10 µg

Secondary

All lanes:

goat anti-rabbit IgG, (H+L), peroxidase conjugated at 1/1000 dilution

Predicted band size: 33 kDa

Observed band size: 40 kDa

true

  • Carrier free

    Anti-RIMS3 antibody [EPR10117(2)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10117(2)

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RIMS3 also known as Regulating Synaptic Membrane Exocytosis 3 is a protein around 170 kDa in size. It plays a role in the modulation of synaptic vesicle exocytosis. RIMS3 is expressed mainly in neuronal tissues and shows localization at presynaptic active zones. This protein is part of the Rab3-interacting molecule family which contributes to the intricate machinery involved in neurotransmitter release at synapses by interacting with other proteins important for synaptic transmission.
Biological function summary

The function of RIMS3 revolves around its role in synaptic processes. RIMS3 contributes to the regulation of synaptic vesicle priming and neurotransmitter release. It functions as part of a protein complex that includes other synaptic proteins like Munc13 and RIM-binding protein. These interactions stabilize synaptic transmission and maintain precise communication between neurons. The absence or alteration of RIMS3 can disrupt these processes and result in altered synaptic strength and plasticity.

Pathways

RIMS3 participates in synaptic vesicle cycle and neurotransmitter release pathways. It interacts with members of the Rab family such as Rab3 playing a part in the vesicle docking and priming steps critical for synaptic activity. Through these pathways RIMS3 aligns functionally with related proteins like Synaptotagmin and SNARE complex components amplifying the efficiency of synaptic vesicle release which underpins neuronal communication and network activity.

Alterations in RIMS3 expression associate with neurological conditions such as autism spectrum disorder (ASD) and schizophrenia. Mutations or disruptions in RIMS3 or its related pathways can affect synaptic efficiency contributing to these disorders. Other synaptic proteins like Neurexin and Neuroligin also connect to these synaptic deficits reinforcing the link between proper RIMS3 function and neural health. Understanding the precise involvement of RIMS3 in these diseases may guide therapeutic approaches aimed at restoring normal synaptic function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulates synaptic membrane exocytosis.
See full target information RIMS3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular cancer 22:206 PubMed38093346

2023

Dynamic altruistic cooperation within breast tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Muhammad Sufyan Bin Masroni,Kee Wah Lee,Victor Kwan Min Lee,Siok Bian Ng,Chao Teng Law,Kok Siong Poon,Bernett Teck-Kwong Lee,Zhehao Liu,Yuen Peng Tan,Wee Ling Chng,Steven Tucker,Lynette Su-Mien Ngo,George Wai Cheong Yip,Min En Nga,Susan Swee Shan Hue,Thomas Choudary Putti,Boon Huat Bay,Qingsong Lin,Lihan Zhou,Mikael Hartman,Tze Ping Loh,Manikandan Lakshmanan,Sook Yee Lee,Vinay Tergaonkar,Huiwen Chua,Adeline Voon Hui Lee,Eric Yew Meng Yeo,Mo-Huang Li,Chan Fong Chang,Zizheng Kee,Karen Mei-Ling Tan,Soo Yong Tan,Evelyn Siew-Chuan Koay,Marco Archetti,Sai Mun Leong
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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