JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB138097

Anti-RIN1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal RIN1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RIN1.

View Alternative Names

Ras and Rab interactor 1, Ras inhibitor JC99, Ras interaction/interference protein 1, RIN1

1 Images
Western blot - Anti-RIN1 antibody (AB138097)
  • WB

Unknown

Western blot - Anti-RIN1 antibody (AB138097)

All lanes:

Western blot - Anti-RIN1 antibody (ab138097) at 1/500 dilution

All lanes:

COLO205 cell lysate at 30 µg

Predicted band size: 84 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human RIN1. The exact immunogen used to generate this antibody is proprietary information.

Q13671

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab138097 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RIN1 also known as Ras and Rab interactor 1 is a protein that plays a role in intracellular signaling. It has a molecular mass of approximately 80 kDa. RIN1 interacts with both Ras and Rab GTPases and acts as a guanine nucleotide exchange factor (GEF) for these proteins. In terms of expression researchers have detected RIN1 in various tissues including the brain and embryonic fibroblasts indicating its involvement in multiple cellular processes.
Biological function summary

RIN1 modulates signaling pathways by influencing the activation state of Ras-related GTPases. It forms part of a larger signaling complex that regulates endocytosis and trafficking of receptors. This activity is essential for receptor-mediated signaling and cellular communication. By affecting these processes RIN1 contributes significantly to the regulation of cytoskeletal dynamics which impacts cell movement and morphology.

Pathways

RIN1 is directly involved in the Ras signaling pathway which is important for cell growth and differentiation. Through its interaction with Ras proteins RIN1 influences downstream effectors like Raf kinases and PI3K which further modulate signaling cascades. RIN1 also participates in the regulation of other pathways linked to receptor internalization partnering with proteins such as Rab5 to coordinate endocytic trafficking.

Disruptions or alterations in RIN1 function have been associated with certain cancers notably lung and breast cancer. These associations highlight its role in abnormal cell proliferation and survival. Moreover RIN1's interactions with Ras proteins correlate with mutations that lead to oncogenic transformations. Understanding RIN1's normal and pathological roles helps reveal potential therapeutic targets for diseases related to Ras-driven signaling dysregulation.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
See full target information RIN1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of molecular endocrinology 68:63-76 PubMed34752415

2021

Non-cell autonomous mechanisms control mitochondrial gene dysregulation in polycystic ovary syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Alba Moreno-Asso,Ali Altıntaş,Luke C McIlvenna,Rhiannon K Patten,Javier Botella,Andrew J McAinch,Raymond J Rodgers,Romain Barrès,Nigel K Stepto
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB172976

Anti-RIN1 (phospho S351) antibody [EPR2734(2)]

RabMAb|Recombinant

Western blot - Anti-RIN1 (phospho S351) antibody [EPR2734(2)] (AB172976)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB62341

Anti-RFP antibody

Lab Essentials

Western blot - Anti-RFP antibody (AB62341)

  • 4
  • 23
Primary Antibodies

AB76785

Anti-PPP1R15B antibody

  • 0
  • 0
Primary Antibodies

AB185921

Anti-RFP antibody [EPR18992]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-RFP antibody [EPR18992] (AB185921)

  • 0
  • 0
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com