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AB243527

Anti-RINL antibody

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(1 Publication)

Rabbit Polyclonal RINL antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RINL aa 200 to C-terminus.

View Alternative Names

Ras and Rab interactor-like protein, RINL

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RINL antibody (AB243527)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RINL antibody (AB243527)

Formalin-fixed, paraffin-embedded human lymph node tissue stained for RINL with ab243527 at 1/500 dilution in immunohistochemical analysis.

Western blot - Anti-RINL antibody (AB243527)
  • WB

Supplier Data

Western blot - Anti-RINL antibody (AB243527)

All lanes:

Western blot - Anti-RINL antibody (ab243527) at 0.4 µg/mL

Lane 1:

RT4 (Human urinary bladder cancer cell line) cell lysate

Lane 2:

U-251 MG (Human brain glioma cell line) cell lysate

Lane 3:

Human plasma (IgG/HSA depleted)

Lane 4:

Human liver tissue

Lane 5:

Human tonsil tissue

Predicted band size: 50 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human RINL aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6ZS11

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The RINL protein also known as Ras and Rab interactor-like protein plays a mechanical role in the regulation of intracellular trafficking. It weighs approximately 25 kDa and localizes within the cytoplasm and cell membrane expressing prominently in neuronal tissues. RINL interacts with small GTPases binding strongly to the GDP-bound form which allows it to act as an effector molecule.
Biological function summary

The functions of RINL involve modulating endosomal transport securing its position as a component of vesicular trafficking processes. It belongs to the RIN family aiding in its role through interaction with Rab GTPase contributing to vesicle docking and fusion. RINL also associates with cytoskeletal elements assisting in the architectural organization of vesicles within cells.

Pathways

The involvement of RINL in intracellular trafficking links it significantly to the endocytic and recycling pathways. It facilitates the sorting of cargo through endosomal networks important for maintaining cellular homeostasis. RINL shares a close pathway relationship with Rab5 and Rab7 both integral to endosomal dynamics which highlights its part in regulating early to late endosome maturation.

RINL's role in neural tissue emphasizes its potential link to neurodegenerative diseases such as Alzheimer's disease. This association becomes apparent through its relation with cellular pathways that involve the amyloid precursor protein (APP) which undergoes endosomal processing. Additionally an imbalance in RINL function may relate to certain forms of epilepsy with possible connections to proteins like the neurotransmitter receptor GABA_A further highlighting its influence on neural excitability and stability.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity).
See full target information RINL
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Science advances 11:eadv8640 PubMed40512859

2025

Interaction between NF-κB and PLAC8 impairs autophagy providing a survival advantage to prostate cells transformed by cadmium.

Applications

Unspecified application

Species

Unspecified reactive species

Vaibhav Shukla,Ashish Tyagi,Balaji Chandrasekaran,Bhawna Tyagi,Balpreet Singh,Thulasidharan Nair Devanarayanan,Venkatesh Kolluru,Murali K Ankem,Chendil Damodaran
View all publications
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Product promise

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