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AB91476

Anti-RIP140 antibody

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(3 Publications)

Goat Polyclonal RIP140 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human Nuclear receptor-interacting protein 1 aa 1050-1100.

View Alternative Names

Nuclear receptor-interacting protein 1, Nuclear factor RIP140, Receptor-interacting protein 140, NRIP1

1 Images
Western blot - Anti-RIP140 antibody (AB91476)
  • WB

Unknown

Western blot - Anti-RIP140 antibody (AB91476)

All lanes:

Western blot - Anti-RIP140 antibody (ab91476) at 0.5 µg/mL

All lanes:

Human Cerebellum lysate (in RIPA buffer) at 35 µg

Predicted band size: 127 kDa

Observed band size: 140 kDa

true

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Nuclear receptor-interacting protein 1 aa 1050-1100. The exact immunogen used to generate this antibody is proprietary information.

P48552

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Alternative Products

Primary Antibodies

AB53740

Anti-RIP140 antibody [2656C6a]

Western blot - Anti-RIP140 antibody [2656C6a] (AB53740)

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Primary Antibodies

AB42126

Anti-RIP140 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RIP140 antibody (AB42126)

  • 4
  • 1

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Secondary Antibodies

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Primary Antibodies

AB300617

Anti-RIP antibody [EPR24883-85]

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Immunohistochemistry - Anti-RIP antibody [EPR24883-85] (AB300617)

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Primary Antibodies

AB184718

Anti-MLKL antibody [EPR17514]

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Western blot - Anti-MLKL antibody [EPR17514] (AB184718)

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Primary Antibodies

AB62344

Anti-RIP3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RIP3 antibody (AB62344)

  • 5
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab91476 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RIP140 also known as receptor-interacting protein 140 and NRIP1 is a protein that acts as a transcriptional corepressor. It has a molecular mass of approximately 115 kDa. RIP140 is found in various tissues with high levels of expression observed in the ovary testes and adipose tissue. This protein interacts with nuclear receptors and influences gene expression by recruiting chromatin-modifying enzymes.
Biological function summary

RIP140 functions in regulating energy homeostasis and reproductive processes. It plays an important role in the repression of genes involved in metabolism and fat storage. RIP140 does not act alone but is part of transcriptional complexes that modulate the activity of multiple facets of gene expression. Its ability to interact with histone deacetylases and other corepressors enhances its regulatory capacity.

Pathways

RIP140 is involved in pathways that govern glucose and lipid metabolism. It interacts notably with PPAR (peroxisome proliferator-activated receptors) and LXR (liver X receptors) both important in lipid metabolism. Energy balance influences genes that RIP140 represses or activates positioning it as a central player in metabolic regulation.

RIP140's role becomes apparent in obesity and type 2 diabetes. Abnormal expression or function of RIP140 affects metabolic pathways contributing to these conditions. The protein also interacts with PGC-1α an important regulator of mitochondrial biogenesis linking it to metabolic health and disease states. Such interactions highlight the protein's significance in maintaining normal physiological balance and its potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression : stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed : 28381549).
See full target information Nuclear receptor-interacting protein 1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Aging 14:3529-3539 PubMed35460552

2022

NRIP1 aggravates lung injury caused by in mice by increasing PIAS1 ubiquitination.

Applications

Unspecified application

Species

Unspecified reactive species

Miaoyi Huang,Jianying Li,Jie Bai,Xusheng Du,Hua Guo,Bo Wang,Jiru Xu

Cancer medicine 8:7762-7773 PubMed31663688

2019

COX7A1 suppresses the viability of human non-small cell lung cancer cells via regulating autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Zhao,Xin Chen,Yetong Feng,Guangsuo Wang,Imran Nawaz,Lifu Hu,Pengfei Liu

Journal of virology 93: PubMed31434735

2019

Long Noncoding RNA Lnc-MxA Inhibits Beta Interferon Transcription by Forming RNA-DNA Triplexes at Its Promoter.

Applications

Unspecified application

Species

Unspecified reactive species

Xinda Li,Guijie Guo,Min Lu,Wenjia Chai,Yucen Li,Xiaomei Tong,Jing Li,Xiaojuan Jia,Wenjun Liu,Dandan Qi,Xin Ye
View all publications
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Product promise

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