JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB93858

Anti-RL2 antibody

Be the first to review this product! Submit a review

|

(3 Publications)

Rabbit Polyclonal ICP0 antibody. Suitable for ELISA, WB and reacts with Recombinant fragment - Human herpesvirus 2 strain HG52 samples. Cited in 3 publications.

View Alternative Names

Trans acting transcriptional protein ICP0, VMW118 protein

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

WB, ELISA

applications

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human herpesvirus 2 strain HG52": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab93858 is purified by antigen specific affinity chromatography. Purity is >90%.
Storage buffer
pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein RL2 also known as RAD51-like protein 2 or RFS-1 plays a mechanical role in homologous recombination an important process for DNA repair. RL2 has a mass of approximately 37 kDa. It expresses across many tissues in the body indicating its widespread functional importance. This protein shares structural and functional homology with RAD51 a well-studied recombinase suggesting that RL2 has similar interactions with DNA.
Biological function summary

RL2 facilitates the repair of DNA double-strand breaks. It forms part of a complex that promotes the search for homologous sequences which is critical for accurate DNA repair and genome stability. This complex allows for the alignment of homologous DNA strands facilitating strand exchange and repair in eukaryotic cells. The high expression of RL2 in dividing cells aligns with its role in maintaining genomic integrity especially during the cell cycle where DNA replication and repair happen frequently.

Pathways

RL2 integrates into networks that involve DNA damage response pathways including the homologous recombination repair pathway. It interacts closely with other proteins such as RAD51 and BRCA2 both of which are essential players in this pathway ensuring precise DNA repair and therefore cell survival. The RAD51-mediated DNA repair pathway restores genetic material that could otherwise lead to mutagenesis if left unrepaired.

Alterations in RL2 expression link to cancer. As an important participant in DNA repair loss of function or dysregulation may lead to genomic instability a hallmark of cancer. Additionally RL2 interacts with BRCA2 mutations of which are associated with an increased risk of breast and ovarian cancers. Studying RL2's interactions in these contexts may provide insight into tumor development and progression making it a potential target for therapeutic interventions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information RL2
style
left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

EMBO reports 24:e56458 PubMed37249035

2023

O-GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance.

Applications

Unspecified application

Species

Unspecified reactive species

Yangzhi Liu,Kairan Yu,Keren Zhang,Mingshan Niu,Qiushi Chen,Yajie Liu,Lingyan Wang,Nana Zhang,Wenli Li,Xiaomin Zhong,Guohui Li,Sijin Wu,Jianing Zhang,Yubo Liu

Nature communications 11:5898 PubMed33214551

2020

Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.

Applications

Unspecified application

Species

Unspecified reactive species

Yubo Liu,Qiushi Chen,Nana Zhang,Keren Zhang,Tongyi Dou,Yu Cao,Yimin Liu,Kun Li,Xinya Hao,Xueqin Xie,Wenli Li,Yan Ren,Jianing Zhang

Nature communications 8:1491 PubMed29133780

2017

O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress.

Applications

Unspecified application

Species

Unspecified reactive species

Cuifang Han,Yuchao Gu,Hui Shan,Wenyi Mi,Jiahui Sun,Minghui Shi,Xinling Zhang,Xinzhi Lu,Feng Han,Qianhong Gong,Wengong Yu
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB2739

Anti-O-Linked N-Acetylglucosamine antibody [RL2]

Immunocytochemistry/ Immunofluorescence - Anti-O-Linked N-Acetylglucosamine antibody [RL2] (AB2739)

  • 5
  • 18
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB177941

Anti-OGT / O-Linked N-Acetylglucosamine Transferase antibody [EPR12713]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OGT / O-Linked N-Acetylglucosamine Transferase antibody [EPR12713] (AB177941)

  • 5
  • 3
Primary Antibodies

AB201995

HRP Anti-O-Linked N-Acetylglucosamine antibody [RL2]

Western blot - HRP Anti-O-Linked N-Acetylglucosamine antibody [RL2] (AB201995)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com