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AB234185

Anti-RLTPR antibody [EM-53]

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(1 Publication)

Mouse Monoclonal RLTPR antibody. Suitable for Flow Cyt (Intra) and reacts with Recombinant fragment - Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Carmil2 aa 1100 to C-terminus.

View Alternative Names

LRRC16C, RLTPR, CARMIL2, Capping protein regulator and myosin 1 linker 2, F-actin-uncapping protein RLTPR, Leucine-rich repeat-containing protein 16C

1 Images
Flow Cytometry (Intracellular) - Anti-RLTPR antibody [EM-53] (AB234185)
  • Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-RLTPR antibody [EM-53] (AB234185)

Intracellular staining of RLTPR stable transfectants with ab234185 (red).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

EM-53

Isotype

IgG1

Carrier free

No

Applications

Flow Cyt (Intra)

applications

Immunogen

Recombinant Fragment Protein within Mouse Carmil2 aa 1100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q3V3V9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Mouse": { "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Recombinant fragment - Mouse": { "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1-4 µg/mL", "FlowCytIntra-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Purified from hybridoma culture supernatant.
Storage buffer
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RLTPR also known as CARMIL2 is a protein involved in T-cell receptor (TCR) signaling. It has a molecular mass of approximately 150 kDa. It is expressed mainly in lymphoid tissues including the thymus and spleen playing an important role in the immune response. RLTPR serves as an adapter protein mediating interactions that are important for signal transduction in immune cells.
Biological function summary

RLTPR supports the activation and proliferation of T-cells by interacting with other intracellular molecules. It forms a complex with the scaffold protein CARD11 and the coiled-coil domain of caspase recruitment domains aiding in the assembly of the immune synapse. This assembly promotes effective T-cell receptor signaling facilitating the immune system's capacity to recognize and react to foreign antigens.

Pathways

RLTPR plays a significant role in the NF-kB signaling pathway which regulates the expression of genes involved in the immune and inflammatory responses. It interacts with proteins such as BCL10 and MALT1 within this pathway contributing to the activation of transcription factors that drive gene expression. RLTPR is also linked to the mTORC1 pathway correlating with processes of cell growth and metabolism.

Disruptions of RLTPR function have been implicated in immunodeficiency and autoimmune disorders. Deficiencies in RLTPR can lead to compromised immune systems often resulting in conditions such as common variable immunodeficiency (CVID). In the context of autoimmune disorders RLTPR abnormalities may contribute to the misregulation of T-cell activation linking it to related proteins such as RHOA that are involved in cell signaling and immune responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed : 26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed : 19846667, PubMed : 26466680, PubMed : 26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed : 19846667, PubMed : 26466680, PubMed : 26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed : 27647348, PubMed : 27647349, PubMed : 28112205).
See full target information CARMIL2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature nanotechnology 19:1224-1233 PubMed38802667

2024

Virus-like structures for combination antigen protein mRNA vaccination.

Applications

Unspecified application

Species

Unspecified reactive species

Jingjing Zhang,Yanmei Li,Fengyuan Zeng,Changyong Mu,Change Liu,Lichun Wang,Xiaowu Peng,Liping He,Yanrui Su,Hongbing Li,An Wang,Lin Feng,Dongxiu Gao,Zhixiao Zhang,Gang Xu,Yixuan Wang,Rong Yue,Junbo Si,Lichun Zheng,Xiong Zhang,Fuyun He,Hongkun Yi,Zhongshu Tang,Gaocan Li,Kaili Ma,Qihan Li
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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