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AB121111

Anti-RNASE6 antibody

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(2 Publications)

Rabbit Polyclonal RNASE6 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RNASE6 aa 1 to C-terminus.

View Alternative Names

RNS6, RNASE6, Ribonuclease K6, RNase K6

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RNASE6 antibody (AB121111)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RNASE6 antibody (AB121111)

Immunohistochemical staining of Human liver shows moderate cytoplasmic positivity in hepatocytes, ab121111 used at a dilution of 1/25.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human RNASE6 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q93091

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p>Use buffer at pH 6 for antigen retrieval.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RNASE6 also called ribonuclease K6 is a member of the ribonuclease A superfamily. It has a molecular mass around 16 kDa. This protein shows ribonuclease activity meaning it can degrade RNA molecules. RNASE6 is expressed in several tissues and cells including leukocytes. Its enzymatic action contributes to the defense system by degrading foreign RNA and may influence inflammatory responses.
Biological function summary

Ribonuclease K6 plays a part in the immune response. It acts as a single entity rather than as part of a complex. This protein helps to defend the body against pathogens by breaking down their RNA reducing their ability to multiply and spread. Beyond its antiviral action RNASE6 can modulate immune cell functions making it a potential component in controlling inflammation and autoimmunity.

Pathways

Several immune-associated cascades involve ribonuclease K6. Specifically RNASE6 intersects with the pathways responsible for pathogen recognition and immune cell activation. These pathways involve proteins such as toll-like receptors (TLRs) which detect microbial components and cytokines which coordinate immune responses. RNASE6 helps in the breakdown of RNA from invading pathogens in these pathways supporting the overall defense mechanism.

Possible links exist between ribonuclease K6 and conditions like infections and inflammatory diseases. In antimicrobial defense RNASE6 may affect the body's susceptibility to bacterial infections. Moreover its role in the immune system suggests potential involvement in autoimmune disorders where the body's immune system mistakenly attacks its own tissues. Studies hint at an interplay between RNASE6 and cytokines which are key players in both fighting infections and driving autoimmune responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed : 27013146, PubMed : 8836175). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed : 25075772, PubMed : 27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed : 27089320). Probably contributes to urinary tract sterility (PubMed : 25075772). Bactericidal activity is independent of RNase activity (PubMed : 27089320).
See full target information RNASE6
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 13:1017120 PubMed36189307

2022

A novel immune cell signature for predicting osteosarcoma prognosis and guiding therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Runsang Pan,Feng Pan,Zhirui Zeng,Shan Lei,Yan Yang,Yushi Yang,Chujiao Hu,Houping Chen,Xiaobin Tian

Kidney international 87:151-61 PubMed25075772

2014

Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract.

Applications

Unspecified application

Species

Unspecified reactive species

Brian Becknell,Tad E Eichler,Susana Beceiro,Birong Li,Robert S Easterling,Ashley R Carpenter,Cindy L James,Kirk M McHugh,David S Hains,Santiago Partida-Sanchez,John D Spencer
View all publications
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