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AB200713

Anti-RND2 antibody

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(1 Publication)

Rabbit Polyclonal RND2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RND2 aa 150 to C-terminus.

View Alternative Names

ARHN, RHO7, RND2, Rho-related GTP-binding protein RhoN, Rho family GTPase 2, Rho-related GTP-binding protein Rho7, Rnd2

1 Images
Western blot - Anti-RND2 antibody (AB200713)
  • WB

Supplier Data

Western blot - Anti-RND2 antibody (AB200713)

All lanes:

Western blot - Anti-RND2 antibody (ab200713) at 1/500 dilution

Lane 1:

HEK293T whole cell lysate

Lane 2:

sp2/0 whole cell lysate

Lane 3:

PC12 whole cell lysate

Predicted band size: 25 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human RND2 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P52198

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Western blot - Anti-HEATR1 antibody (AB200693)

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WASF2/WAVE2 antibody (AB204376)

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Primary Antibodies

AB200376

Anti-Zinc finger MIZ domain-containing protein 1 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Zinc finger MIZ domain-containing protein 1 antibody - N-terminal (AB200376)

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  • 0
Primary Antibodies

AB176594

Anti-ZZEF1 antibody

Immunoprecipitation - Anti-ZZEF1 antibody (AB176594)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab200713 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Storage buffer
pH: 7.2 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RND2 also known as Rhonadin-2 is a small GTP-binding protein with a molecular weight of approximately 24 kDa. It belongs to the Rho family of GTPases and functions mechanically as a regulator of the actin cytoskeleton. This protein controls cellular processes such as migration and cytoskeletal organization through its ability to cycle between an active GTP-bound state and an inactive GDP-bound state. RND2 is expressed in various tissues but shows significant presence in the neural tissues where it plays an important role in neuronal morphology.
Biological function summary

This protein plays a significant role in neuronal development and differentiation. It is not typically a part of other protein complexes but directly interacts with effector proteins involved in actin dynamics. RND2 modulates processes such as axonal guidance and dendritic spine formation contributing to nerve cell communication and network formation during brain development. Its ability to control actin polymerization helps in shaping the structural integrity of neurons which is essential for their proper functioning.

Pathways

RND2 influences cellular actions by integrating into the actin cytoskeleton signaling pathway and the neurotrophin signaling pathway. The actin cytoskeleton pathway involves changes in cell shape and movement through interactions with proteins like ROCK2 and cofilin which RND2 regulates. Neurotrophin pathways affect neuronal survival and growth where RND2 acts alongside proteins like NTRK2 impacting the development and maintenance of the neuronal system.

RND2 has implications in neurodevelopmental disorders and cancer. Mutations or dysregulation of this protein might contribute to conditions like intellectual disability due to its critical role in neuronal development. Moreover aberrant expression of RND2 links to cancer metastasis as its regulation of cell movement and invasion can drive tumor progression. In cancer RND2 interacts with proteins like Rac1 affecting pathways that control tumor cell migration and invasion.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).
See full target information RND2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Microbiology and immunology 66:433-441 PubMed35568971

2022

Diagnostic value of lncRNA NORAD in pulmonary tuberculosis and its regulatory role in Mycobacterium tuberculosis infection of macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Wenna Sun,Xiong He,Xiushuang Zhang,Xiaomeng Wang,Wen Lin,Xiaofeng Wang,Yan Liang
View all publications
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Product promise

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